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Gene Review: 

aat  -  leucyl/phenylalanyl-tRNA--protein transferase

Escherichia coli CFT073

 
 
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Disease relevance of aat

  • To prove the essential involvement of the fcs, ech, and aat genes in the catabolism of ferulic acid and eugenol in Pseudomonas sp. strain HR199, these genes were inactivated separately by the insertion of omega elements [1].
 

High impact information on aat

  • Eubacterial leucyl/phenylalanyl-tRNA protein transferase (L/F-transferase), encoded by the aat gene, conjugates leucine or phenylalanine to the N-terminal Arg or Lys residue of proteins, using Leu-tRNA(Leu) or Phe-tRNA(Phe) as a substrate [2].
 

Associations of aat with chemical compounds

  • The aat gene product was shown not to be involved in this catabolism, thus excluding a beta-oxidation analogous degradation pathway for ferulic acid [1].

References

  1. Biochemical and genetic analyses of ferulic acid catabolism in Pseudomonas sp. Strain HR199. Overhage, J., Priefert, H., Steinbüchel, A. Appl. Environ. Microbiol. (1999) [Pubmed]
  2. Crystal structures of leucyl/phenylalanyl-tRNA-protein transferase and its complex with an aminoacyl-tRNA analog. Suto, K., Shimizu, Y., Watanabe, K., Ueda, T., Fukai, S., Nureki, O., Tomita, K. EMBO J. (2006) [Pubmed]
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