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Gene Review:

ftsK - DNA translocase FtsK

Escherichia coli CFT073

Wang, L. et al., Goehring, N.W. et al., Yu, X.C. et al., Dorazi, R. et al.

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Disease relevance of ftsK

The role of ftsK in the growth of Escherichia coli was examined by turning off its expression [1].
Escherichia coli cell division protein FtsK is a homolog of Bacillus subtilis SpoIIIE and appears to act late in the septation process [2].

High impact information on ftsK

The expression of ftsK increased as part of the SOS response, and increased expression of ftsK conferred increased resistance to DNA damage [1].
Rather, this mutation acts as a general suppressor of division defects, which include deletions of the normally essential genes zipA and ftsK and mutations in FtsQ that affect both localization and recruitment [3].
The SOS promoter dinH is essential for ftsK transcription during cell division [4].

References

FtsK is an essential cell division protein that is localized to the septum and induced as part of the SOS response. Wang, L., Lutkenhaus, J. Mol. Microbiol. (1998) [Pubmed]
Localization of cell division protein FtsK to the Escherichia coli septum and identification of a potential N-terminal targeting domain. Yu, X.C., Tran, A.H., Sun, Q., Margolin, W. J. Bacteriol. (1998) [Pubmed]
Mutants, Suppressors, and Wrinkled Colonies: Mutant Alleles of the Cell Division Gene ftsQ Point to Functional Domains in FtsQ and a Role for Domain 1C of FtsA in Divisome Assembly. Goehring, N.W., Petrovska, I., Boyd, D., Beckwith, J. J. Bacteriol. (2007) [Pubmed]
The SOS promoter dinH is essential for ftsK transcription during cell division. Dorazi, R., Dewar, S.J. Microbiology (Reading, Engl.) (2000) [Pubmed]

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