Gene Review:
Gpc5 - glypican 5
Mus musculus
Synonyms:
A230034F01Rik, Glypican-5
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High impact information on Gpc5
- Interestingly, glypican-5 localizes to 13q31-32 of the human genome, deletions of which are associated with human 13q- syndrome, a developmental disorder with a pattern of defects that shows significant overlap with the pattern of glypican-5 expression [1].
- Glypican-5 mRNA is detected as a 3.9- and 4.4-kb transcript in adult and neonatal mouse brain total RNA, and in situ hybridization results localize transcript primarily to restricted regions of the developing central nervous system, limb, and kidney in patterns consistent with a role in the control of cell growth or differentiation [1].
References
- Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain. Saunders, S., Paine-Saunders, S., Lander, A.D. Dev. Biol. (1997) [Pubmed]
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