Disease relevance of GPC5

• Our findings suggest that GPC5 is a likely target for amplification, and that over-expression of this gene may contribute to development and/or progression of lymphomas and other tumors [1].
• Furthermore, the properties of GPC5 make it an attractive target for therapeutic intervention in rhabdomyosarcomas and other tumors that amplify and/or overexpress the gene [2].

Psychiatry related information on GPC5

• Mutation screening of two candidate genes from 13q32 in families affected with Bipolar disorder: human peptide transporter (SLC15A1) and human glypican5 (GPC5) [3].

High impact information on GPC5

• Recurrent high-level amplifications were identified at 18q21 containing BCL2, and at 13q31 containing GPC5 [4].
• A correlation between expression levels of nascent pre-rRNA and GPC5 (P = 0.001), but not a C13orf25 transcript containing miR-17-92, in primary samples supports an association of GPC5 with proliferative capacity in vivo [2].
• Our data are consistent with a role of GPC5, in the context of sarcomagenesis, in enhancing FGF signaling that leads to mesodermal cell proliferation without induction of myogenic differentiation [2].
• Genomic copy number and gene expression analyses of rhabdomyosarcomas indicated that GPC5 was the only gene consistently expressed and up-regulated in all cases with amplification [2].
• We show that GPC5 increases proliferation through potentiating the action of the growth factors fibroblast growth factor 2 (FGF2), hepatocyte growth factor (HGF), and Wnt1A [2].

Biological context of GPC5

• We report the construction of a high-resolution 4 Mb sequence-ready BAC/PAC contig of the GPC5/GPC6 gene cluster on chromosome region 13q32 [5].
• A 4-Mb BAC/PAC contig and complete genomic structure of the GPC5/GPC6 gene cluster on chromosome 13q32 [5].
• Constitutive overexpression and knockdown of GPC5 expression in rhabdomyosarcoma cell lines increased and decreased cell proliferation, respectively [2].
• We then screened the 65 expressed sequence tags and Glypican 5 (GPC5) by reverse transcription-PCR and Northern blotting [6].
• Sequencing of the exons did not reveal mutations in the GPC5 gene in the 7 families affected with BP [3].

Anatomical context of GPC5

• GPC5 was over-expressed in lymphoma cell lines that had shown amplification, in comparison with those that had not [1].

Other interactions of GPC5

• Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family [7].

References