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Gene Review:

def - peptide deformylase

Escherichia coli CFT073

Teo, J.W. et al., Meinnel, T. et al., Meinnel, T. et al.

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Disease relevance of def

Essentiality of the def gene, encoding PDF from Mycobacterium tuberculosis, was demonstrated through genetic knockout experiments with Mycobacterium bovis BCG [1].
Evidence that peptide deformylase and methionyl-tRNA(fMet) formyltransferase are encoded within the same operon in Escherichia coli [2].
Characterization of the Thermus thermophilus locus encoding peptide deformylase and methionyl-tRNA(fMet) formyltransferase [3].

High impact information on def

Peptide deformylase (PDF) catalyzes the hydrolytic removal of the N-terminal formyl group from nascent proteins [1].

References

Peptide deformylase inhibitors as potent antimycobacterial agents. Teo, J.W., Thayalan, P., Beer, D., Yap, A.S., Nanjundappa, M., Ngew, X., Duraiswamy, J., Liung, S., Dartois, V., Schreiber, M., Hasan, S., Cynamon, M., Ryder, N.S., Yang, X., Weidmann, B., Bracken, K., Dick, T., Mukherjee, K. Antimicrob. Agents Chemother. (2006) [Pubmed]
Evidence that peptide deformylase and methionyl-tRNA(fMet) formyltransferase are encoded within the same operon in Escherichia coli. Meinnel, T., Blanquet, S. J. Bacteriol. (1993) [Pubmed]
Characterization of the Thermus thermophilus locus encoding peptide deformylase and methionyl-tRNA(fMet) formyltransferase. Meinnel, T., Blanquet, S. J. Bacteriol. (1994) [Pubmed]

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