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Disease relevance of Mycobacterium


Psychiatry related information on Mycobacterium


High impact information on Mycobacterium

  • This is in keeping with other evidence showing that susceptible humans generate some level of Th1 immunity to Mycobacterium tuberculosis (Mtb) infection [7].
  • In this issue of Cell, a study by Valerie Mizrahi and her colleagues suggests that a putative error-prone DNA polymerase encoded by the dnaE2 gene of Mycobacterium tuberculosis may bypass certain types of DNA base damage, generating mutations [8].
  • Here, we provide evidence for the involvement of the specific trisaccharide unit of the phenolic glycolipid-1 (PGL-1) of Mycobacterium leprae in determining the bacterial predilection to the peripheral nerve [9].
  • RESULTS: Among patients with no prior treatment, a median of 9.9 percent of Mycobacterium tuberculosis strains were resistant to at least one drug (range, 2 to 41 percent); resistance to isoniazid (7.3 percent) or streptomycin (6.5 percent) was more common than resistance to rifampin (1.8 percent) or ethambutol (1.0 percent) [10].
  • Prophylaxis against disseminated Mycobacterium avium complex with weekly azithromycin, daily rifabutin, or both. California Collaborative Treatment Group [1].

Chemical compound and disease context of Mycobacterium


Biological context of Mycobacterium


Anatomical context of Mycobacterium


Gene context of Mycobacterium


Analytical, diagnostic and therapeutic context of Mycobacterium


  1. Prophylaxis against disseminated Mycobacterium avium complex with weekly azithromycin, daily rifabutin, or both. California Collaborative Treatment Group. Havlir, D.V., Dubé, M.P., Sattler, F.R., Forthal, D.N., Kemper, C.A., Dunne, M.W., Parenti, D.M., Lavelle, J.P., White, A.C., Witt, M.D., Bozzette, S.A., McCutchan, J.A. N. Engl. J. Med. (1996) [Pubmed]
  2. A randomized trial of clarithromycin as prophylaxis against disseminated Mycobacterium avium complex infection in patients with advanced acquired immunodeficiency syndrome. Pierce, M., Crampton, S., Henry, D., Heifets, L., LaMarca, A., Montecalvo, M., Wormser, G.P., Jablonowski, H., Jemsek, J., Cynamon, M., Yangco, B.G., Notario, G., Craft, J.C. N. Engl. J. Med. (1996) [Pubmed]
  3. The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis. Zhang, Y., Heym, B., Allen, B., Young, D., Cole, S. Nature (1992) [Pubmed]
  4. Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells. Zuany-Amorim, C., Sawicka, E., Manlius, C., Le Moine, A., Brunet, L.R., Kemeny, D.M., Bowen, G., Rook, G., Walker, C. Nat. Med. (2002) [Pubmed]
  5. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Kamijo, R., Harada, H., Matsuyama, T., Bosland, M., Gerecitano, J., Shapiro, D., Le, J., Koh, S.I., Kimura, T., Green, S.J. Science (1994) [Pubmed]
  6. Effect of trifluoperazine, a potential drug for tuberculosis with psychotic disorders, on the growth of clinical isolates of drug resistant Mycobacterium tuberculosis. Gadre, D.V., Talwar, V., Gupta, H.C., Murthy, P.S. International clinical psychopharmacology. (1998) [Pubmed]
  7. Immunity to tuberculosis. North, R.J., Jung, Y.J. Annu. Rev. Immunol. (2004) [Pubmed]
  8. TB or Not TB: how Mycobacterium tuberculosis may evade drug treatment. Friedberg, E.C., Fischhaber, P.L. Cell (2003) [Pubmed]
  9. Role of the cell wall phenolic glycolipid-1 in the peripheral nerve predilection of Mycobacterium leprae. Ng, V., Zanazzi, G., Timpl, R., Talts, J.F., Salzer, J.L., Brennan, P.J., Rambukkana, A. Cell (2000) [Pubmed]
  10. Global surveillance for antituberculosis-drug resistance, 1994-1997. World Health Organization-International Union against Tuberculosis and Lung Disease Working Group on Anti-Tuberculosis Drug Resistance Surveillance. Pablos-Méndez, A., Raviglione, M.C., Laszlo, A., Binkin, N., Rieder, H.L., Bustreo, F., Cohn, D.L., Lambregts-van Weezenbeek, C.S., Kim, S.J., Chaulet, P., Nunn, P. N. Engl. J. Med. (1998) [Pubmed]
  11. Mycobacterium chelonae wound infections after plastic surgery employing contaminated gentian violet skin-marking solution. Safranek, T.J., Jarvis, W.R., Carson, L.A., Cusick, L.B., Bland, L.A., Swenson, J.M., Silcox, V.A. N. Engl. J. Med. (1987) [Pubmed]
  12. Humoral and cell-mediated immune responses to live recombinant BCG-HIV vaccines. Aldovini, A., Young, R.A. Nature (1991) [Pubmed]
  13. The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol. Telenti, A., Philipp, W.J., Sreevatsan, S., Bernasconi, C., Stockbauer, K.E., Wieles, B., Musser, J.M., Jacobs, W.R. Nat. Med. (1997) [Pubmed]
  14. Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus. Scorpio, A., Zhang, Y. Nat. Med. (1996) [Pubmed]
  15. Mycobacterium microti may protect itself from intracellular destruction by releasing cyclic AMP into phagosomes. Lowrie, D.B., Jackett, P.S., Ratcliffe, N.A. Nature (1975) [Pubmed]
  16. The glyoxylate cycle is required for fungal virulence. Lorenz, M.C., Fink, G.R. Nature (2001) [Pubmed]
  17. Vaccination against tuberculosis by DNA injection. Tascon, R.E., Colston, M.J., Ragno, S., Stavropoulos, E., Gregory, D., Lowrie, D.B. Nat. Med. (1996) [Pubmed]
  18. In vitro growth of Mycobacterium lepraemurium, an obligate intracellular microbe. Dhople, A.M., Hanks, J.H. Science (1977) [Pubmed]
  19. The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Kang, C.M., Abbott, D.W., Park, S.T., Dascher, C.C., Cantley, L.C., Husson, R.N. Genes Dev. (2005) [Pubmed]
  20. Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin. Temmerman, S., Pethe, K., Parra, M., Alonso, S., Rouanet, C., Pickett, T., Drowart, A., Debrie, A.S., Delogu, G., Menozzi, F.D., Sergheraert, C., Brennan, M.J., Mascart, F., Locht, C. Nat. Med. (2004) [Pubmed]
  21. TRAIL-R as a negative regulator of innate immune cell responses. Diehl, G.E., Yue, H.H., Hsieh, K., Kuang, A.A., Ho, M., Morici, L.A., Lenz, L.L., Cado, D., Riley, L.W., Winoto, A. Immunity (2004) [Pubmed]
  22. Phenolic glycolipid-1 of Mycobacterium leprae binds complement component C3 in serum and mediates phagocytosis by human monocytes. Schlesinger, L.S., Horwitz, M.A. J. Exp. Med. (1991) [Pubmed]
  23. DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells. Tailleux, L., Schwartz, O., Herrmann, J.L., Pivert, E., Jackson, M., Amara, A., Legres, L., Dreher, D., Nicod, L.P., Gluckman, J.C., Lagrange, P.H., Gicquel, B., Neyrolles, O. J. Exp. Med. (2003) [Pubmed]
  24. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Banerjee, A., Dubnau, E., Quemard, A., Balasubramanian, V., Um, K.S., Wilson, T., Collins, D., de Lisle, G., Jacobs, W.R. Science (1994) [Pubmed]
  25. Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Flynn, J.L., Goldstein, M.M., Chan, J., Triebold, K.J., Pfeffer, K., Lowenstein, C.J., Schreiber, R., Mak, T.W., Bloom, B.R. Immunity (1995) [Pubmed]
  26. Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide. Kamijo, R., Le, J., Shapiro, D., Havell, E.A., Huang, S., Aguet, M., Bosland, M., Vilcek, J. J. Exp. Med. (1993) [Pubmed]
  27. TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis. Bafica, A., Scanga, C.A., Feng, C.G., Leifer, C., Cheever, A., Sher, A. J. Exp. Med. (2005) [Pubmed]
  28. Secreted lymphotoxin-alpha is essential for the control of an intracellular bacterial infection. Roach, D.R., Briscoe, H., Saunders, B., France, M.P., Riminton, S., Britton, W.J. J. Exp. Med. (2001) [Pubmed]
  29. Diversification of T cell responses to carboxy-terminal determinants within the 65-kD heat-shock protein is involved in regulation of autoimmune arthritis. Moudgil, K.D., Chang, T.T., Eradat, H., Chen, A.M., Gupta, R.S., Brahn, E., Sercarz, E.E. J. Exp. Med. (1997) [Pubmed]
  30. Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88. Fremond, C.M., Yeremeev, V., Nicolle, D.M., Jacobs, M., Quesniaux, V.F., Ryffel, B. J. Clin. Invest. (2004) [Pubmed]
  31. Detection of mycobacterial DNA in sarcoidosis and tuberculosis with polymerase chain reaction. Saboor, S.A., Johnson, N.M., McFadden, J. Lancet (1992) [Pubmed]
  32. Tuberculosis in the 1990s. Barnes, P.F., Barrows, S.A. Ann. Intern. Med. (1993) [Pubmed]
  33. Clarithromycin therapy for bacteremic Mycobacterium avium complex disease. A randomized, double-blind, dose-ranging study in patients with AIDS. AIDS Clinical Trials Group Protocol 157 Study Team. Chaisson, R.E., Benson, C.A., Dube, M.P., Heifets, L.B., Korvick, J.A., Elkin, S., Smith, T., Craft, J.C., Sattler, F.R. Ann. Intern. Med. (1994) [Pubmed]
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