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Gene Review

SEC24B  -  SEC24 family member B

Homo sapiens

Synonyms: Protein transport protein Sec24B, SEC24-related protein B
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High impact information on SEC24B

  • The half times for Sar1p, Sec23p, and Sec24p turnover are 1.1, 3.7, and 3.9 s, respectively [1].
  • Sec24 proteins and sorting at the endoplasmic reticulum [2].
  • We also show that buds on the ER, ER exit sites and COPII vesicles are markedly depleted in mitotic cells and COPII components Sec23p, Sec24p, Sec13p and Sec31p redistribute into the cytosol, indicating ER export is inhibited at an early stage [3].

Analytical, diagnostic and therapeutic context of SEC24B


  1. Secretory cargo regulates the turnover of COPII subunits at single ER exit sites. Forster, R., Weiss, M., Zimmermann, T., Reynaud, E.G., Verissimo, F., Stephens, D.J., Pepperkok, R. Curr. Biol. (2006) [Pubmed]
  2. Sec24 proteins and sorting at the endoplasmic reticulum. Pagano, A., Letourneur, F., Garcia-Estefania, D., Carpentier, J.L., Orci, L., Paccaud, J.P. J. Biol. Chem. (1999) [Pubmed]
  3. Evidence for prebudding arrest of ER export in animal cell mitosis and its role in generating Golgi partitioning intermediates. Prescott, A.R., Farmaki, T., Thomson, C., James, J., Paccaud, J.P., Tang, B.L., Hong, W., Quinn, M., Ponnambalam, S., Lucocq, J. Traffic (2001) [Pubmed]
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