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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CGRRF1  -  cell growth regulator with ring finger...

Homo sapiens

Synonyms: CGR19, Cell growth regulator with RING finger domain protein 1, Cell growth regulatory gene 19 protein, RING finger protein 197, RNF197
 
 
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High impact information on CGRRF1

  • Two previously uncharacterized cDNAs, cell growth regulatory (CGR) genes CGR11 and CGR19, were isolated [1].
  • The predicted amino acid sequence of these novel proteins contain known motifs; EF-hand domains (CGR11) and a ring-finger domain (CGR19), suggestive of function [1].
  • Both CGR11 and CGR19 are able to inhibit the growth of several cell lines [1].
  • RING finger domain of RNF26 was most homologous to that of CGR19 (49% amino-acid identity) [2].

References

  1. Induction of cell growth regulatory genes by p53. Madden, S.L., Galella, E.A., Riley, D., Bertelsen, A.H., Beaudry, G.A. Cancer Res. (1996) [Pubmed]
  2. Molecular cloning and characterization of RNF26 on human chromosome 11q23 region, encoding a novel RING finger protein with leucine zipper. Katoh, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
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