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Gene Review

RNF26  -  ring finger protein 26

Homo sapiens

Synonyms: MGC2642, RING finger protein 26
 
 
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Disease relevance of RNF26

 

High impact information on RNF26

  • We have cloned and characterized MFRP and RNF26 genes at 11q23 [2].
  • The RNF26 gene on human chromosome 11q23 region was found to encode a polypeptide of 433 amino acids with the N-terminal leucine zipper domain and the C-terminal RING finger domain [1].
  • Although substrates of ubiquitination mediated by RNF26 remain to be elucidated, RNF26 upregulation in several types of human cancer might be implicated in carcinogenesis through dysregulation of its substrates [1].
  • RING finger domain of RNF26 was most homologous to that of CGR19 (49% amino-acid identity) [1].
  • The 3.2-kb RNF26 mRNA was expressed ubiquitously in normal human tissues, but was upregulated in several human cancer cell lines, including HL-60 (promyelocytic leukemia), HeLa S3 (cervical uterus cancer), SW480 (colorectal cancer), and MKN7 (gastric cancer) [1].
 

Analytical, diagnostic and therapeutic context of RNF26

References

 
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