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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Rdh1  -  retinol dehydrogenase 1 (all trans)

Mus musculus

 
 
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High impact information on Rdh1

  • These data provide insight into the features necessary to orient type III (reverse signal-anchor) proteins and demonstrate that Rdh1, Crad1, and other short-chain dehydrogenases/reductases, which share similar N-terminal signaling sequences such as human Rdh5 and mouse Rdh4, orient with their catalytic domains facing the cytoplasm [1].
  • Rdh1 has three transcription start sites in kidney and one start site in liver [2].
  • Rdh1 consists of four exons and three introns and spans approximately 14412 bp [2].
 

Anatomical context of Rdh1

  • An N-terminal signaling sequence of 22 residues, consisting of a hydrophobic helix ending in a net positive charge, anchors Rdh1 and Crad1 in the endoplasmic reticulum facing the cytoplasm [1].

References

  1. Elements in the N-terminal signaling sequence that determine cytosolic topology of short-chain dehydrogenases/reductases. Studies with retinol dehydrogenase type 1 and cis-retinol/androgen dehydrogenase type 1. Zhang, M., Hu, P., Napoli, J.L. J. Biol. Chem. (2004) [Pubmed]
  2. Gene structure and minimal promoter of mouse rdh1. Zhang, M., Thomas, B.C., Napoli, J.L. Gene (2003) [Pubmed]
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