Gene Review:
dhrs9 - dehydrogenase/reductase (SDR family) member 9
Danio rerio
Synonyms:
RDHA, SO:0000704, rdh1l, wu:fb64b07, zgc:73286
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Disease relevance of rdh1l
- We report that adenomatous polyposis coli (APC) mutant zebrafish harbor an RA-deficient phenotype including aberrant intestinal differentiation and that these mutants can be rescued by treatment with retinoic acid or injection of rdh1l mRNA [1].
High impact information on rdh1l
- Further, we have found that although APC mutants are deficient in rdh1l expression, they harbor increased expression of raldh2 suggesting the control of RA production by APC is via retinol dehydrogenase activity [1].
- Herein, we report that the novel retinol dehydrogenase, rdh1l, is required for proper gut development and differentiation. rdh1l is expressed ubiquitously during early development but becomes restricted to the gut by 3 days postfertilization [1].
- Knockdown of rdh1l results in a robust RA-deficient phenotype including lack of intestinal differentiation, which can be rescued by the addition of exogenous retinoic acid [1].
- The zebrafish retinol dehydrogenase, rdh1l, is essential for intestinal development and is regulated by the tumor suppressor adenomatous polyposis coli [1].
Other interactions of rdh1l
- These results provide genetic evidence that retinoic acid is required for vertebrate gut development and that the tumor suppressor APC controls the production of RA in the gut by regulating the expression of the retinol dehydrogenase, rdh1l [1].
References
- The zebrafish retinol dehydrogenase, rdh1l, is essential for intestinal development and is regulated by the tumor suppressor adenomatous polyposis coli. Nadauld, L.D., Shelton, D.N., Chidester, S., Yost, H.J., Jones, D.A. J. Biol. Chem. (2005) [Pubmed]
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