Gene Review:
Mtv48 - mammary tumor virus locus 48
Mus musculus
Synonyms:
Mtv-44, Mtv-48
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Disease relevance of Mtv48
- The nucleotide sequences of the open reading frames in the 3' long terminal repeats of Mtv-48 and -51 were very similar to those of Mtv-DDO, mouse mammary tumor virus C4 [MMTV(C4)], and MMTV(BALB/cV), which encode V beta 2-specific superantigens [1].
- These results indicate that the provirus Mtv-48 but not Mtv-51 is capable of producing a milk-borne virus of which the superantigen stimulates V beta 2-expressing T cells [1].
High impact information on Mtv48
- Here we show by backcross analysis that both Mtv-48 and -51 cosegregate with very slow deletion of T cells bearing V beta 2 [1].
- The nucleotide sequences of MMTV(CS) open reading frame were completely matched with those of Mtv-48 [1].
- We have previously reported new Mtv loci, Mtv-48 and -51, in the Japanese laboratory mouse strains CS and NC [1].
Other interactions of Mtv48
References
- A novel V beta 2-specific endogenous mouse mammary tumor virus which is capable of producing a milk-borne exogenous virus. Niimi, N., Wajjwalku, W., Ando, Y., Nakamura, N., Ueda, M., Yoshikai, Y. J. Virol. (1995) [Pubmed]
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