The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Mice

  • Several different MMTV proviruses present in laboratory mice have segregated like stable, independent genetic elements during the inbreeding which followed a cross between Bagg albino and DBA mice 60 years ago [1].
  • The Thy-1 (theta) antigen was identified in wild mice (Mus musculus), the frequency of its alleles was determined in two natural populations of wild mice, and the possible T-cell origin of spontaneous lymphomas was investigated in one of these populations [2].
  • The ip application of a single dose of 1,000 mg Ro 10-9359/kg to female Swiss mice with chemically induced skin papillomas caused a 29% regression of the mean tumor diameter after 3 days and a 51% regression after 7 days [3].
  • Relationship between organotropism and leukemogenicity of type C RNA viruses as demonstrated in NIH Swiss mice inoculated at birth with Gross murine leukemia virus [4].
  • Infection of Swiss mouse 3T3FL cells with a clonal isolate of Moloney leukemia virus (MLV-IC) resulted in virus progeny composed of at least three different murine helper oncornaviruses [5].
  • BALB/c mice are susceptible to Leishmania major, whereas strain STS/A is resistant to this parasite [6]. Seventeen Lmr loci that control this strain difference have been mapped (reviewed in [7].

Psychiatry related information on Mice


High impact information on Mice

  • To test directly whether the glutamine-rich region is required for Sry function in vivo, we created truncation mutations of the Mus musculus musculus Sry gene and tested their ability to induce testis formation in XX embryos using a transgenic mouse assay [13].
  • In mice (genus Mus) Sry also includes a large CAG trinucleotide repeat region encoding a carboxy-terminal glutamine-rich domain that acts as a transcriptional trans-activator in vitro [13].
  • Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice [14].
  • In contrast, we report that the murine locus, Csf2ra, maps to an autosome in the laboratory mouse [15].
  • We have found a paternally nonimprinted Tme variant in crosses of Thp females with Mus m. musculus males [16].

Chemical compound and disease context of Mice


Biological context of Mice


Anatomical context of Mice


Associations of Mice with chemical compounds


Gene context of Mice

  • Studies were performed in euthymic and athymic NIH Swiss mice 28 days PI and in the presence or absence of treatment with corticosteroid or COX inhibitors [36].
  • Genetic analysis using an interspecies (Mus musculus X Mus spretus) back-cross confirmed this assignment by demonstrating that both the GM-CSF and Multi-CSF genes are genetically linked to the SPARC gene, which had been independently assigned to sub-band B1 of chromosome 11 [37].
  • A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene [38].
  • In this report, the role of the H19 gene in its own imprinting is investigated by introducing a Mus spretus H19 gene into heterologous locations in the mouse genome [39].
  • Five probes localizing to the Xq26-Xqter region of the human X chromosome have been genetically mapped on the mouse X chromosome using an interspecific cross involving Mus spretus to a contiguous region lying proximally to the Tabby (Ta) locus [40].

Analytical, diagnostic and therapeutic context of Mice

  • Understanding the action of genetic factors, such as Cinda1 [46] , Cinda2 [46], Cinda3 [47], Cinda4 [47] and Cinda5 [47] that control T cell function is expected to contribute to the efficient analysis of the genetic control of susceptibility to infections, cancer and autoimmune diseases [46].


  1. Endogenous mammary tumour virus DNA varies among wild mice and segregates during inbreeding. Cohen, J.C., Varmus, H.E. Nature (1979) [Pubmed]
  2. Immunogenetics of a thymus antigen in lymphoma-prone and lymphoma-resistant colonies of wild mice. Blankenhorn, E.P., Gardner, M.B., Estes, J.D. J. Natl. Cancer Inst. (1975) [Pubmed]
  3. Autoradiographic and histopathologic studies on the mode of action of an aromatic retinoid (Ro 10-9359) on chemically induced epithelial tumors in Swiss mice. Frigg, M., Torhorst, J. J. Natl. Cancer Inst. (1977) [Pubmed]
  4. Relationship between organotropism and leukemogenicity of type C RNA viruses as demonstrated in NIH Swiss mice inoculated at birth with Gross murine leukemia virus. Nagao, K., Kodama, Y., Hamada, K., Yokoro, K. J. Natl. Cancer Inst. (1978) [Pubmed]
  5. A novel murine oncornavirus with dual eco- and xenotropic properties. Fischinger, P.J., Nomura, S., Bolognesi, D.P. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  6. Resistance to Leishmania major in Mice. Demant, P., Lipoldova, M., Svobodova, M. Science. (1996) [Pubmed]
  7. Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis. Lipoldová, M., Demant, P. Nat. Rev. Genet. (2006) [Pubmed]
  8. Effect of midbrain raphe lesion on avoidance learning in aggressive mice. Valzelli, L., Bernasconi, S., Bohlken, S. Biol. Psychiatry (1976) [Pubmed]
  9. Novel potent AMPA/kainate receptor antagonists: synthesis and anticonvulsant activity of a series of 2-[(4-alkylsemicarbazono)-(4-amino-phenyl)methyl]-4,5-methylenedioxyphenylacetic acid alkyl esters. Micale, N., Zappalà, M., Grasso, S., Puja, G., De Sarro, G., Ferreri, G., De Sarro, A., Toma, L., De Micheli, C. J. Med. Chem. (2002) [Pubmed]
  10. Time course of the locomotor stimulant and depressant effects of a single low dose of ethanol in mice. Smoothy, R., Berry, M.S. Psychopharmacology (Berl.) (1985) [Pubmed]
  11. RO 15-4513 and FG 7142 reverse the reduction in social behavior caused by ethanol in mice. Hilakivi, L.A., Lister, R.G. Eur. J. Pharmacol. (1988) [Pubmed]
  12. Pairing alters the effect of progesterone on nesting in female C57BL/10Sn mice. Possidente, B., Nath, S., Smith, L. Physiol. Behav. (1988) [Pubmed]
  13. Sry requires a CAG repeat domain for male sex determination in Mus musculus. Bowles, J., Cooper, L., Berkman, J., Koopman, P. Nat. Genet. (1999) [Pubmed]
  14. Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice. Rugarli, E.I., Adler, D.A., Borsani, G., Tsuchiya, K., Franco, B., Hauge, X., Disteche, C., Chapman, V., Ballabio, A. Nat. Genet. (1995) [Pubmed]
  15. The human pseudoautosomal GM-CSF receptor alpha subunit gene is autosomal in mouse. Disteche, C.M., Brannan, C.I., Larsen, A., Adler, D.A., Schorderet, D.F., Gearing, D., Copeland, N.G., Jenkins, N.A., Park, L.S. Nat. Genet. (1992) [Pubmed]
  16. Genetic analysis of genomic imprinting: an Imprintor-1 gene controls inactivation of the paternal copy of the mouse Tme locus. Forejt, J., Gregorová, S. Cell (1992) [Pubmed]
  17. Chemical transformation of rat cells infected with xenotropic type-C RNA virus and its suppression by virus-specific antiserum. Price, P.J., Suk, W.A., Peters, R.L., Gilden, R.V., Huebner, R.J. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  18. Modification of early dimethylhydrazine carcinogenesis by colonic mucosal hyperplasia. Barthold, S.W., Beck, D. Cancer Res. (1980) [Pubmed]
  19. Hematogenous origin of the inflammatory response in acute poliomyelitis. Wolinsky, J.S., Jubelt, B., Burke, S., Narayan, O. Ann. Neurol. (1982) [Pubmed]
  20. Quantification of bleomycin pulmonary toxicity in mice by changes in lung hydroxyproline content and morphometric histopathology. Sikic, B.I., Young, D.M., Mimnaugh, E.G., Gram, T.E. Cancer Res. (1978) [Pubmed]
  21. Genetic alterations of p53 and ras genes in 1,3-butadiene- and 2',3'-dideoxycytidine-induced lymphomas. Zhuang, S.M., Cochran, C., Goodrow, T., Wiseman, R.W., Söderkvist, P. Cancer Res. (1997) [Pubmed]
  22. A single locus in the mouse encodes both myosin light chains 1 and 3, a second locus corresponds to a related pseudogene. Robert, B., Daubas, P., Akimenko, M.A., Cohen, A., Garner, I., Guenet, J.L., Buckingham, M. Cell (1984) [Pubmed]
  23. Regulation of 40S ribosomal protein S6 phosphorylation in Swiss mouse 3T3 cells. Thomas, G., Siegmann, M., Kubler, A.M., Gordon, J., Jimenez de Asua, L. Cell (1980) [Pubmed]
  24. Pheromonally induced sexual maturation in females: regulation by the social environment of the male. Lombardi, J.R., Vandenbergh, J.G. Science (1977) [Pubmed]
  25. Further evidence that BALB/c and C57BL/6 gamma 2a genes originate from two distinct isotypes. Morgado, M.G., Cam, P., Gris-Liebe, C., Cazenave, P.A., Jouvin-Marche, E. EMBO J. (1989) [Pubmed]
  26. Isolation of a B-tropic type-C virus from reticulum cell neoplasms induced in BALB/c mice by SJL/J type-C virus. Chang, K.S., Aoki, T., Law, L.W. J. Natl. Cancer Inst. (1975) [Pubmed]
  27. Schwannoma-derived growth factor must be transported into the nucleus to exert its mitogenic activity. Kimura, H. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  28. Platelet-derived growth factor stimulates tyrosine-specific protein kinase activity in Swiss mouse 3T3 cell membranes. Nishimura, J., Huang, J.S., Deuel, T.F. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  29. Cytogenetic damage induced by folate deficiency in mice is enhanced by caffeine. MacGregor, J.T., Schlegel, R., Wehr, C.M., Alperin, P., Ames, B.N. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  30. Polycyclic aromatic hydrocarbon mutagenesis of human epidermal keratinocytes in culture. Allen-Hoffmann, B.L., Rheinwald, J.G. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  31. EGF, PGF2 alpha and insulin induce the phosphorylation of identical S6 peptides in swiss mouse 3T3 cells: effect of cAMP on early sites of phosphorylation. Martin-Pérez, J., Siegmann, M., Thomas, G. Cell (1984) [Pubmed]
  32. Carcinogenicity testing of herbicide 2,4,5-trichlorophenoxyethanol containing dioxin and of pure dioxin in Swiss mice. Tóth, K., Somfai-Relle, S., Sugár, J., Bence, J. Nature (1979) [Pubmed]
  33. Strange females increase plasma testosterone levels in male mice. Macrides, F., Bartke, A., Dalterio, S. Science (1975) [Pubmed]
  34. Anticonvulsant action of excitatory amino acid antagonists. Croucher, M.J., Collins, J.F., Meldrum, B.S. Science (1982) [Pubmed]
  35. Glyoxalase I polymorphism in the mouse: a new genetic marker linked to H-2. Meo, T., Douglas, T., Rijnbeek, A.M. Science (1977) [Pubmed]
  36. Role of immunologic factors and cyclooxygenase 2 in persistent postinfective enteric muscle dysfunction in mice. Barbara, G., De Giorgio, R., Deng, Y., Vallance, B., Blennerhassett, P., Collins, S.M. Gastroenterology (2001) [Pubmed]
  37. Close genetic and physical linkage between the murine haemopoietic growth factor genes GM-CSF and Multi-CSF (IL3). Barlow, D.P., Bućan, M., Lehrach, H., Hogan, B.L., Gough, N.M. EMBO J. (1987) [Pubmed]
  38. A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene. Ye, X., Zhu, C., Harper, J.W. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  39. The structural H19 gene is required for transgene imprinting. Pfeifer, K., Leighton, P.A., Tilghman, S.M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  40. Detailed ordering of markers localizing to the Xq26-Xqter region of the human X chromosome by the use of an interspecific Mus spretus mouse cross. Avner, P., Amar, L., Arnaud, D., Hanauer, A., Cambrou, J. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  41. Suppression of infectious murine leukemia virus in wild mice (Mus musculus) by passive immunization. Gardner, M.B., Klement, V., Estes, J.D., Gilden, R.V., Toni, R., Huebner, R.J. J. Natl. Cancer Inst. (1977) [Pubmed]
  42. Conservation of the immunoglobulin C lambda 5 gene in the Mus gene. Mami, F., Cazenave, P.A., Kindt, T.J. EMBO J. (1988) [Pubmed]
  43. Imprinting of a RING zinc-finger encoding gene in the mouse chromosome region homologous to the Prader-Willi syndrome genetic region. Jong, M.T., Carey, A.H., Caldwell, K.A., Lau, M.H., Handel, M.A., Driscoll, D.J., Stewart, C.L., Rinchik, E.M., Nicholls, R.D. Hum. Mol. Genet. (1999) [Pubmed]
  44. Subcellular localization of prostaglandin-forming cyclooxygenase in Swiss mouse 3T3 fibroblasts by electron microscopic immunocytochemistry. Rollins, T.E., Smith, W.L. J. Biol. Chem. (1980) [Pubmed]
  45. Construction and isolation of a transforming murine retrovirus containing the src gene of Rous sarcoma virus. Anderson, S.M., Scolnick, E.M. J. Virol. (1983) [Pubmed]
  46. IL-2-induced proliferative response is controlled by loci Cinda1 and Cinda2 on mouse chromosomes 11 and 12: a distinct control of the response induced by different IL-2 concentrations. Krulová, M., Havelková, H., Kosarová, M., Holán, V., Hart, A.A., Demant, P., Lipoldová, M. Genomics. (1997) [Pubmed]
  47. Novel loci controlling lymphocyte proliferative response to cytokines and their clustering with loci controlling autoimmune reactions, macrophage function and lung tumor susceptibility. Lipoldová, M., Havelková, H., Badalová, J., Demant, P. Int. J. Cancer. (2005) [Pubmed]
WikiGenes - Universities