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Gene Review

Sle5  -  systemic lupus erythematosus susceptibility 5

Mus musculus

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Disease relevance of Sle5

  • On the non-autoimmune C57BL/6 (B6) background, the chromosome 7-derived lupus susceptibility loci Sle3 and Sle5 have been shown to mediate an elevated CD4:CD8 ratio with an increase in activated CD4(+) T cells, decreased susceptibility to apoptosis, and a break in humoral tolerance [1].


  1. Genetic dissection of systemic lupus erythematosus pathogenesis: evidence for functional expression of Sle3/5 by non-T cells. Sobel, E.S., Morel, L., Baert, R., Mohan, C., Schiffenbauer, J., Wakeland, E.K. J. Immunol. (2002) [Pubmed]
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