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Gene Review

Ccua  -  curlicue a

Mus musculus

 
 
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High impact information on Ccua

  • Dnahc8, an axonemal dynein heavy chain gene, is a strong candidate for the proximal factor, Ccua, but the identity of the distal factor, Ccub, is unknown [1].
  • More recent heterospecific breeding experiments between Mus spretus (Spretus) and Mus musculus domesticus (Domesticus) have mapped the primary source(s) of both "curlicue" and "whipless" to a small sub-locus of Hst6, Curlicue a (Ccua) [2].
 

Biological context of Ccua

  • SSR content analysis of 23 BACs mapping to four contigs within the Hst6 locus has resulted in isolation of proximal and distal recombinant breakpoints circumscribing the flagellar assembly phenotype/Ccua factor [3].
 

Other interactions of Ccua

  • Recent studies have shown that the complete presentation of "curlicue" derives from expression of at least two factors within the locus, Curlicue a (Ccua) proximally and Curlicue b (Ccub) distally, with a factor affecting sperm-oolemma penetration, Stop1p, mapping between them [3].

References

  1. The mouse T complex gene Tsga2, encoding polypeptides located in the sperm tail and anterior acrosome, maps to a locus associated with sperm motility and sperm-egg interaction abnormalities. Hui, L., Lu, J., Han, Y., Pilder, S.H. Biol. Reprod. (2006) [Pubmed]
  2. An axonemal dynein at the Hybrid Sterility 6 locus: implications for t haplotype-specific male sterility and the evolution of species barriers. Fossella, J., Samant, S.A., Silver, L.M., King, S.M., Vaughan, K.T., Olds-Clarke, P., Johnson, K.A., Mikami, A., Vallee, R.B., Pilder, S.H. Mamm. Genome (2000) [Pubmed]
  3. Mapping and cloning recombinant breakpoints demarcating the hybrid sterility 6-specific sperm tail assembly defect. Samant, S.A., Fossella, J., Silver, L.M., Pilder, S.H. Mamm. Genome (1999) [Pubmed]
 
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