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Gene Review

Dnah8  -  dynein, axonemal, heavy chain 8

Mus musculus

Synonyms: ATPase, Axonemal beta dynein heavy chain 8, Ciliary dynein heavy chain 8, Dnahc8, Dynein heavy chain 8, axonemal, ...
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Disease relevance of Dnahc8


Psychiatry related information on Dnahc8


High impact information on Dnahc8

  • The murine La protein and the RNA binding subclass of calf thymus La protein showed ATPase/dATPase activity in the presence of DNA-RNA or RNA-RNA hybrids [8].
  • Nitric oxide (NO) physiologically stimulates the sarco/endoplasmic reticulum calcium (Ca(2+)) ATPase (SERCA) to decrease intracellular Ca(2+) concentration and relax cardiac, skeletal and vascular smooth muscle [9].
  • The most potent compounds inhibited the helicase, the primase and the DNA-dependent ATPase activities of the enzyme with IC50 (50% inhibitory concentration) values less than 100 nM [10].
  • A complementary DNA encoding the entire alpha 1 subunit of the mouse Na+- and K+-dependent adenosine triphosphatase (ATPase) was inserted into the expression vector pSV2 [11].
  • The ability to assay the biological activity of this ATPase in a transfection protocol permits the application of molecular genetic techniques to the analysis of structure-function relationships for the enzyme that establishes the internal Na+/K+ environment of most animal cells [11].

Chemical compound and disease context of Dnahc8


Biological context of Dnahc8


Anatomical context of Dnahc8

  • The cumulative data imply that Dnahc8 may have acquired functional plasticity in the testis through the tightly controlled expression of both typical and unusual isoforms [1].
  • We explored the roles of SWI/SNF-like BAF chromatin remodeling complexes in this process by progressive deletion of the ATPase subunit, Brg, through successive stages of early T cell development [18].
  • The ATPase p97, a prototype of this superfamily, participates in organelle membrane fusion [19].
  • Tape-stripping of murine abdominal wall skin achieved almost complete depletion of epidermal Langerhans cells within a few hours of application, as measured by cell surface ATPase and expression of Ia antigens [20].
  • The characteristics of the interstitial dendritic cell found in heart were studied in detail, and this cell was shown to be negative for acid phosphatase, beta-glucuronidase, and ATPase activity, and certainly some and probably all of the cells were negative for nonspecific esterase activity [21].

Associations of Dnahc8 with chemical compounds

  • Furthermore, incubation of Møs with sodium nitroprusside mimicked the L-arginine-dependent inhibition of H+ ATPase activity [22].
  • In C57BL/1 mice analyses were done on ouabain-insensitive ATPase, 5'-nucleotidase, nonspecific esterase, and beta-glucuronidase, but no diet effects were seen [23].
  • Loss of cell adenylates could not be explained by arrest of de novo purine synthesis or increased ATP consumption by the Na+-K+ ATPase or the mitochondrial F0-ATPase [24].
  • To investigate the effects of proximal tubule NO on Na+/K(+)-ATPase, we induced NO production in mouse proximal tubule epithelial cells by treatment with lipopolysaccharide (LPS) and interferon-gamma (IFN gamma) followed by determinations of ouabain-sensitive ATPase activity [25].
  • Despite the inability of the H(+)/K(+) ATPase to be endocytosed, the gastric acid secretory response to histamine or an antagonist was very similar to that of wild-type mice, indicating that control of H(+)/K(+) ATPase activity can occur independently of intracellular trafficking [26].

Physical interactions of Dnahc8

  • Sarcolipin (SLN) inhibits the cardiac sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) by direct binding and is superinhibitory if it binds as a binary complex with phospholamban (PLN) [27].
  • This finding rules out the possibility that contaminating F0 ATPase gives rise to the DCCD binding exhibited by PLP and confirms the possibility that PLP has proton channel activity, as suggested by Lin and Lees (1,2) [28].
  • The high affinity for actin and the slow rate of ADP release helps the myosin head to remain attached to actin for a large fraction of each ATPase cycle and allows actin filaments to be moved by only a few myosin V molecules in vitro [29].

Regulatory relationships of Dnahc8

  • PTH inhibited Na-K ATPase activity in cells expressing wild-type NHERF-1 associated with increased serine phosphorylation of the alpha subunit of the transporter [30].
  • An important role for these cTnT sites is indicated by results demonstrating that ROCK-II induced a depression in tension and ATPase activity in skinned fiber bundles from a TG model in which cTnI is replaced by slow skeletal TnI, which lacks S23 and S24 and in which T144 is replaced by proline [31].
  • We conclude that NO generated by mouse proximal tubule epithelial cell iNOS inhibits Na/K ATPase activity in an autocrine fashion and that this inhibition is accompanied by a reduction in Na-dependent solute transport [25].
  • Residues 2-25 of phospholamban are insufficient to inhibit Ca2+ transport ATPase of cardiac sarcoplasmic reticulum [32].
  • Sarco/endoplasmic reticulum Ca(2+) ATPase 2b was up-regulated to more rapidly remove Ca(2+) from the cytosol of RGS2(-/-) cells [33].

Other interactions of Dnahc8

  • Here we report the complete physical isolation of the Ccua locus and the identification of a candidate gene for expression of both "whipless" and "curlicue" at its proximal end, an axonemal dynein heavy chain gene, Dnahc8, formerly mapped by interspecific backcross analysis near Pim1 [34].
  • Our results argue that Dnahc8 is fundamental to flagellar organization and function in Domesticus, but not Spretus, and suggest that Dnahc8 is integral to both Hst6- and t-specific male infertility [34].
  • The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini [1].
  • Regulation of cytoplasmic dynein ATPase by Lis1 [35].
  • Wilson disease is an autosomal recessive disorder of hepatic copper metabolism caused by mutations in a gene encoding a copper-transporting P-type ATPase [36].

Analytical, diagnostic and therapeutic context of Dnahc8


  1. The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini. Samant, S.A., Ogunkua, O., Hui, L., Fossella, J., Pilder, S.H. Dev. Biol. (2002) [Pubmed]
  2. The mouse t complex distorter/sterility candidate, Dnahc8, expresses a gamma-type axonemal dynein heavy chain isoform confined to the principal piece of the sperm tail. Samant, S.A., Ogunkua, O.O., Hui, L., Lu, J., Han, Y., Orth, J.M., Pilder, S.H. Dev. Biol. (2005) [Pubmed]
  3. Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Sturgill-Koszycki, S., Schlesinger, P.H., Chakraborty, P., Haddix, P.L., Collins, H.L., Fok, A.K., Allen, R.D., Gluck, S.L., Heuser, J., Russell, D.G. Science (1994) [Pubmed]
  4. A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Bultman, S.J., Gebuhr, T.C., Magnuson, T. Genes Dev. (2005) [Pubmed]
  5. An autoimmune disease with multiple molecular targets abrogated by the transgenic expression of a single autoantigen in the thymus. Alderuccio, F., Toh, B.H., Tan, S.S., Gleeson, P.A., van Driel, I.R. J. Exp. Med. (1993) [Pubmed]
  6. Ontogeny of dexamethasone binding and sodium potassium ATPase activity in experimental murine polycystic kidney disease. Ogborn, M.R., Crocker, J.F. J. Steroid Biochem. Mol. Biol. (1991) [Pubmed]
  7. Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice. Dickey, C.A., Gordon, M.N., Wilcock, D.M., Herber, D.L., Freeman, M.J., Morgan, D. BMC neuroscience [electronic resource]. (2005) [Pubmed]
  8. Characterization of the autoantigen La as a nucleic acid-dependent ATPase/dATPase with melting properties. Bachmann, M., Pfeifer, K., Schröder, H.C., Müller, W.E. Cell (1990) [Pubmed]
  9. S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide. Adachi, T., Weisbrod, R.M., Pimentel, D.R., Ying, J., Sharov, V.S., Schöneich, C., Cohen, R.A. Nat. Med. (2004) [Pubmed]
  10. Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease. Crute, J.J., Grygon, C.A., Hargrave, K.D., Simoneau, B., Faucher, A.M., Bolger, G., Kibler, P., Liuzzi, M., Cordingley, M.G. Nat. Med. (2002) [Pubmed]
  11. Ouabain resistance conferred by expression of the cDNA for a murine Na+, K+-ATPase alpha subunit. Kent, R.B., Emanuel, J.R., Ben Neriah, Y., Levenson, R., Housman, D.E. Science (1987) [Pubmed]
  12. Different mechanisms for suppression of apoptosis by cytokines and calcium mobilizing compounds. Lotem, J., Sachs, L. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  13. A Mg2+- and Ca2+-stimulated adenosine triphosphatase at the outer surface of Ehrlich ascites tumor cells. Ronquist, G., Agren, G.K. Cancer Res. (1975) [Pubmed]
  14. c-Fos degradation by the proteasome. An early, Bcl-2-regulated step in apoptosis. He, H., Qi, X.M., Grossmann, J., Distelhorst, C.W. J. Biol. Chem. (1998) [Pubmed]
  15. Energy-dependent efflux of methotrexate in L1210 leukemia cells. Evidence for the role of an ATPase obtained with inside-out plasma membrane vesicles. Schlemmer, S.R., Sirotnak, F.M. J. Biol. Chem. (1992) [Pubmed]
  16. Sarco-endoplasmic ATPase blocker 2,5-Di(tert-butyl)-1, 4-benzohydroquinone inhibits N-, P-, and Q- but not T-, L-, or R-type calcium currents in central and peripheral neurons. Scamps, F., Vigues, S., Restituito, S., Campo, B., Roig, A., Charnet, P., Valmier, J. Mol. Pharmacol. (2000) [Pubmed]
  17. Pattern of segmental recombination in the distal inversion of mouse t haplotypes. Erhart, M.A., Lekgothoane, S., Grenier, J., Nadeau, J.H. Mamm. Genome (2002) [Pubmed]
  18. Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. Chi, T.H., Wan, M., Lee, P.P., Akashi, K., Metzger, D., Chambon, P., Wilson, C.B., Crabtree, G.R. Immunity (2003) [Pubmed]
  19. A major conformational change in p97 AAA ATPase upon ATP binding. Rouiller, I., Butel, V.M., Latterich, M., Milligan, R.A., Wilson-Kubalek, E.M. Mol. Cell (2000) [Pubmed]
  20. Depletion of epidermal langerhans cells and Ia immunogenicity from tape-stripped mouse skin. Streilein, J.W., Lonsberry, L.W., Bergstresser, P.R. J. Exp. Med. (1982) [Pubmed]
  21. Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain. Hart, D.N., Fabre, J.W. J. Exp. Med. (1981) [Pubmed]
  22. Nitric oxide derived from L-arginine impairs cytoplasmic pH regulation by vacuolar-type H+ ATPases in peritoneal macrophages. Swallow, C.J., Grinstein, S., Sudsbury, R.A., Rotstein, O.D. J. Exp. Med. (1991) [Pubmed]
  23. High-fat diets and fecal level of reductase and colon mucosal level of ornithine decarboxylase, beta-glucuronidase, 5'-nucleotidase, ATPase, and esterase in mice. Temple, N.J., El-Khatib, S.M. J. Natl. Cancer Inst. (1984) [Pubmed]
  24. Alterations in adenosine triphosphate and energy charge in cultured endothelial and P388D1 cells after oxidant injury. Spragg, R.G., Hinshaw, D.B., Hyslop, P.A., Schraufstätter, I.U., Cochrane, C.G. J. Clin. Invest. (1985) [Pubmed]
  25. Autocrine inhibition of Na+/K(+)-ATPase by nitric oxide in mouse proximal tubule epithelial cells. Guzman, N.J., Fang, M.Z., Tang, S.S., Ingelfinger, J.R., Garg, L.C. J. Clin. Invest. (1995) [Pubmed]
  26. Gastric parietal cell acid secretion in mice can be regulated independently of H/K ATPase endocytosis. Nguyen, N.V., Gleeson, P.A., Courtois-Coutry, N., Caplan, M.J., Van Driel, I.R. Gastroenterology (2004) [Pubmed]
  27. Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation. Gramolini, A.O., Trivieri, M.G., Oudit, G.Y., Kislinger, T., Li, W., Patel, M.M., Emili, A., Kranias, E.G., Backx, P.H., Maclennan, D.H. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  28. Analysis of myelin proteolipid protein and F0 ATPase subunit 9 in normal and jimpy CNS. Benjamins, J.A., Studzinski, D.M., Skoff, R.P. Neurochem. Res. (1994) [Pubmed]
  29. Effect of ADP and ionic strength on the kinetic and motile properties of recombinant mouse myosin V. Wang, F., Chen, L., Arcucci, O., Harvey, E.V., Bowers, B., Xu, Y., Hammer, J.A., Sellers, J.R. J. Biol. Chem. (2000) [Pubmed]
  30. Role of NHERF-1 in regulation of the activity of Na-K ATPase and sodium-phosphate co-transport in epithelial cells. Lederer, E.D., Khundmiri, S.J., Weinman, E.J. J. Am. Soc. Nephrol. (2003) [Pubmed]
  31. Functional effects of rho-kinase-dependent phosphorylation of specific sites on cardiac troponin. Vahebi, S., Kobayashi, T., Warren, C.M., de Tombe, P.P., Solaro, R.J. Circ. Res. (2005) [Pubmed]
  32. Residues 2-25 of phospholamban are insufficient to inhibit Ca2+ transport ATPase of cardiac sarcoplasmic reticulum. Jones, L.R., Field, L.J. J. Biol. Chem. (1993) [Pubmed]
  33. Role of regulator of G protein signaling 2 (RGS2) in Ca(2+) oscillations and adaptation of Ca(2+) signaling to reduce excitability of RGS2-/- cells. Wang, X., Huang, G., Luo, X., Penninger, J.M., Muallem, S. J. Biol. Chem. (2004) [Pubmed]
  34. An axonemal dynein at the Hybrid Sterility 6 locus: implications for t haplotype-specific male sterility and the evolution of species barriers. Fossella, J., Samant, S.A., Silver, L.M., King, S.M., Vaughan, K.T., Olds-Clarke, P., Johnson, K.A., Mikami, A., Vallee, R.B., Pilder, S.H. Mamm. Genome (2000) [Pubmed]
  35. Regulation of cytoplasmic dynein ATPase by Lis1. Mesngon, M.T., Tarricone, C., Hebbar, S., Guillotte, A.M., Schmitt, E.W., Lanier, L., Musacchio, A., King, S.J., Smith, D.S. J. Neurosci. (2006) [Pubmed]
  36. Functional expression of the Wilson disease protein reveals mislocalization and impaired copper-dependent trafficking of the common H1069Q mutation. Payne, A.S., Kelly, E.J., Gitlin, J.D. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  37. An RNA polymerase II transcription factor has an associated DNA-dependent ATPase (dATPase) activity strongly stimulated by the TATA region of promoters. Conaway, R.C., Conaway, J.W. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  38. Chromosomal analysis of a diethylnitrosamine-induced tumorigenic and a nontumorigenic rat liver cell line. Holecek, B.U., Kerler, R., Rabes, H.M. Cancer Res. (1989) [Pubmed]
  39. Evidence for the presence of myosin I in the nucleus. Nowak, G., Pestic-Dragovich, L., Hozák, P., Philimonenko, A., Simerly, C., Schatten, G., de Lanerolle, P. J. Biol. Chem. (1997) [Pubmed]
  40. Expression of intrinsic factor in rat and murine gastric mucosal cell lineages is modified by inflammation. Shao, J., Sartor, R.B., Dial, E., Lichtenberger, L.M., Schepp, W., Alpers, D.H. Am. J. Pathol. (2000) [Pubmed]
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