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High impact information on Pcdh3
- We named this protocad herin-3 (Pcdh3) since this is the third protocadherin of which the entire coding sequence has been determined [1].
- Chromosome mapping indicates that mouse Pcdh3 is located in a specific region of mouse chromosome 18, close to the location of previously cloned protocadherins, suggesting that various protocadherins form a cluster in this region [1].
- In contrast to the classical cadherins, however, the expressed Pcdh3 was sensitive to trypsin even in the presence of Ca2+, and the transfectants did not show strong Ca(2+)-dependent cell aggregation activity [1].
- Most of the deduced amino acid sequences of other cDNA clones obtained by the screening show high homology with but are distinct from that of Pcdh3, indicating that most of these sequences correspond to homologous but different protocadherins [1].
Analytical, diagnostic and therapeutic context of Pcdh3
- In situ hybridization results showed that Pcdh3 and its related proteins were expressed at various areas in brain [1].
References
- Cloning, expression, and chromosomal localization of a novel cadherin-related protein, protocadherin-3. Sago, H., Kitagawa, M., Obata, S., Mori, N., Taketani, S., Rochelle, J.M., Seldin, M.F., Davidson, M., St John, T., Suzuki, S.T. Genomics (1995) [Pubmed]
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