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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cell Aggregation

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Disease relevance of Cell Aggregation


High impact information on Cell Aggregation


Chemical compound and disease context of Cell Aggregation


Biological context of Cell Aggregation


Anatomical context of Cell Aggregation

  • In addition, agents that cause elevation of intracellular Ca2+ after entry across the plasma membrane were potent inhibitors of cell aggregation and reduced the N-cadherin- mediated junctions in the cells [21].
  • Similar to phorbol ester-induced homotypic adhesion, cell aggregation triggered through VLA-4 requires the presence of divalent cations, integrity of cytoskeleton and active metabolism [22].
  • We here describe the triggering of homotypic cell aggregation of peripheral blood T lymphocytes and myelomonocytic cells by mAbs specific for certain epitopes of the human VLA alpha 4 subunit [22].
  • These findings suggest that Sp17 promotes heparan sulfate-mediated cell aggregation and thereby plays a role in regulating adhesion and migration of normal and malignant lymphocytes [23].
  • Interestingly, the triggering of cell aggregation through CD45 induced membrane surface relocation of CD45 and LFA-1 molecules, with both of them colocalizing at cell-cell contact areas of B-cell aggregates [24].

Associations of Cell Aggregation with chemical compounds


Gene context of Cell Aggregation

  • ICAM-3-mediated cell aggregation was dependent on the LFA-1/ICAM-1 pathway as demonstrated by blocking experiments with mAbs specific for the LFA-1 and ICAM-1 molecules [30].
  • By using truncated Nrt molecules and a homotypic cell aggregation assay which involves a soluble ligand activity, it has been possible to show that the adhesive function is localized in the N-terminal region of the extracellular domain comprised between His347 and His482 [31].
  • Ectopic expression of both PRR2 cDNAs induced marked cell aggregation [32].
  • Our S2 cell aggregation assays have revealed a heterotypic interaction between Hibris and Dumbfounded, but not between Hibris and Irregular Chiasm-Roughest [33].
  • NSAIDs, if added early during fibroblast aggregation, inhibited HGF/SF production effectively but had no effect at later stages of cell aggregation [34].

Analytical, diagnostic and therapeutic context of Cell Aggregation


  1. Cholesterol-induced growth stimulation, cell aggregation, and membrane properties of ascites tumor cells in culture. Haeffner, E.W., Hoffmann, C.J., Stoehr, M., Scherf, H. Cancer Res. (1984) [Pubmed]
  2. Heregulin beta1-activated phosphatidylinositol 3-kinase enhances aggregation of MCF-7 breast cancer cells independent of extracellular signal-regulated kinase. Tan, M., Grijalva, R., Yu, D. Cancer Res. (1999) [Pubmed]
  3. Proteomics reveal Cochlin deposits associated with glaucomatous trabecular meshwork. Bhattacharya, S.K., Rockwood, E.J., Smith, S.D., Bonilha, V.L., Crabb, J.S., Kuchtey, R.W., Robertson, N.G., Peachey, N.S., Morton, C.C., Crabb, J.W. J. Biol. Chem. (2005) [Pubmed]
  4. Characterization of peptides that bind the tumor-associated Thomsen-Friedenreich antigen selected from bacteriophage display libraries. Peletskaya, E.N., Glinsky, V.V., Glinsky, G.V., Deutscher, S.L., Quinn, T.P. J. Mol. Biol. (1997) [Pubmed]
  5. Identification of genes up-regulated by retinoic-acid-induced differentiation of the human neuronal precursor cell line NTERA-2 cl.D1. Leypoldt, F., Lewerenz, J., Methner, A. J. Neurochem. (2001) [Pubmed]
  6. Identification of a cell surface glycoprotein involved in cell aggregation in D. discoideum. Geltosky, J.E., Weseman, J., Bakke, A., Lerner, R.A. Cell (1979) [Pubmed]
  7. Cells isolated from the embryonic neural retina differ in behavior in vitro and membrane structure. Sheffield, J.B., Pressman, D., Lynch, M. Science (1980) [Pubmed]
  8. The discoidin domain receptor tyrosine kinases are activated by collagen. Vogel, W., Gish, G.D., Alves, F., Pawson, T. Mol. Cell (1997) [Pubmed]
  9. Axon patterning requires DN-cadherin, a novel neuronal adhesion receptor, in the Drosophila embryonic CNS. Iwai, Y., Usui, T., Hirano, S., Steward, R., Takeichi, M., Uemura, T. Neuron (1997) [Pubmed]
  10. Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP. Humtsoe, J.O., Feng, S., Thakker, G.D., Yang, J., Hong, J., Wary, K.K. EMBO J. (2003) [Pubmed]
  11. Shigella flexneri transformants expressing type 1 (mannose-specific) fimbriae bind to, activate, and are killed by phagocytic cells. Gbarah, A., Mirelman, D., Sansonetti, P.J., Verdon, R., Bernhard, W., Sharon, N. Infect. Immun. (1993) [Pubmed]
  12. Inhibition of plaque and caries formation by a glucan produced by Streptococcus mutans mutant UAB108. Takada, K., Shiota, T., Curtiss, R., Michalek, S.M. Infect. Immun. (1985) [Pubmed]
  13. Genetic analysis of a region of the Enterococcus faecalis plasmid pCF10 involved in positive regulation of conjugative transfer functions. Chung, J.W., Bensing, B.A., Dunny, G.M. J. Bacteriol. (1995) [Pubmed]
  14. Inhibition of transforming growth factor-beta 1 alters the growth, anchor-dependent cell aggregation and integrin mRNA expression in human promonocytes: implications for endometriosis and peritoneal adhesion formation. Dou, Q., Williams, R.S., Chegini, N. Mol. Hum. Reprod. (1997) [Pubmed]
  15. Extracellular polysaccharide composition of Azospirillum brasilense and its relation with cell aggregation. Burdman, S., Jurkevitch, E., Soria-Díaz, M.E., Serrano, A.M., Okon, Y. FEMS Microbiol. Lett. (2000) [Pubmed]
  16. Structural requirements for outside-in and inside-out signaling by Drosophila neuroglian, a member of the L1 family of cell adhesion molecules. Hortsch, M., Homer, D., Malhotra, J.D., Chang, S., Frankel, J., Jefford, G., Dubreuil, R.R. J. Cell Biol. (1998) [Pubmed]
  17. Induction of tyrosine phosphorylation during ICAM-3 and LFA-1-mediated intercellular adhesion, and its regulation by the CD45 tyrosine phosphatase. Arroyo, A.G., Campanero, M.R., Sánchez-Mateos, P., Zapata, J.M., Ursa, M.A., del Pozo, M.A., Sánchez-Madrid, F. J. Cell Biol. (1994) [Pubmed]
  18. T-cadherin-mediated cell growth regulation involves G2 phase arrest and requires p21(CIP1/WAF1) expression. Huang, Z.Y., Wu, Y., Hedrick, N., Gutmann, D.H. Mol. Cell. Biol. (2003) [Pubmed]
  19. Human neutrophil-specific granule deficiency: a model to assess the role of neutrophil-specific granules in the evolution of the inflammatory response. Gallin, J.I., Fletcher, M.P., Seligmann, B.E., Hoffstein, S., Cehrs, K., Mounessa, N. Blood (1982) [Pubmed]
  20. Endogenous osteonectin/SPARC/BM-40 expression inhibits MDA-MB-231 breast cancer cell metastasis. Koblinski, J.E., Kaplan-Singer, B.R., VanOsdol, S.J., Wu, M., Engbring, J.A., Wang, S., Goldsmith, C.M., Piper, J.T., Vostal, J.G., Harms, J.F., Welch, D.R., Kleinman, H.K. Cancer Res. (2005) [Pubmed]
  21. Cross talk between adhesion molecules: control of N-cadherin activity by intracellular signals elicited by beta1 and beta3 integrins in migrating neural crest cells. Monier-Gavelle, F., Duband, J.L. J. Cell Biol. (1997) [Pubmed]
  22. An alternative leukocyte homotypic adhesion mechanism, LFA-1/ICAM-1-independent, triggered through the human VLA-4 integrin. Campanero, M.R., Pulido, R., Ursa, M.A., Rodríguez-Moya, M., de Landázuri, M.O., Sánchez-Madrid, F. J. Cell Biol. (1990) [Pubmed]
  23. Sperm protein 17 is expressed on normal and malignant lymphocytes and promotes heparan sulfate-mediated cell-cell adhesion. Lacy, H.M., Sanderson, R.D. Blood (2001) [Pubmed]
  24. B-cell homotypic adhesion through exon-A restricted epitopes of CD45 involves LFA-1/ICAM-1, ICAM-3 interactions, and induces coclustering of CD45 and LFA-1. Zapata, J.M., Campanero, M.R., Marazuela, M., Sánchez-Madrid, F., de Landázuri, M.O. Blood (1995) [Pubmed]
  25. The contact site A glycoprotein mediates cell-cell adhesion by homophilic binding in Dictyostelium discoideum. Siu, C.H., Cho, A., Choi, A.H. J. Cell Biol. (1987) [Pubmed]
  26. Functional cooperation between the neural adhesion molecules L1 and N-CAM is carbohydrate dependent. Kadmon, G., Kowitz, A., Altevogt, P., Schachner, M. J. Cell Biol. (1990) [Pubmed]
  27. Inhibition of red cell aggregation prevents spontaneous echocardiographic contrast formation in human blood. Fatkin, D., Loupas, T., Low, J., Feneley, M. Circulation (1997) [Pubmed]
  28. Inhibition of gonadotropin-induced granulosa cell differentiation by activation of protein kinase C. Shinohara, O., Knecht, M., Catt, K.J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  29. Mouse Na+/K+-ATPase beta1-subunit has a K+-dependent cell adhesion activity for beta-GlcNAc-terminating glycans. Kitamura, N., Ikekita, M., Sato, T., Akimoto, Y., Hatanaka, Y., Kawakami, H., Inomata, M., Furukawa, K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  30. ICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway. Campanero, M.R., del Pozo, M.A., Arroyo, A.G., Sánchez-Mateos, P., Hernández-Caselles, T., Craig, A., Pulido, R., Sánchez-Madrid, F. J. Cell Biol. (1993) [Pubmed]
  31. The structure-function relationships in Drosophila neurotactin show that cholinesterasic domains may have adhesive properties. Darboux, I., Barthalay, Y., Piovant, M., Hipeau-Jacquotte, R. EMBO J. (1996) [Pubmed]
  32. The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule. Lopez, M., Aoubala, M., Jordier, F., Isnardon, D., Gomez, S., Dubreuil, P. Blood (1998) [Pubmed]
  33. Characterization of Drosophila hibris, a gene related to human nephrin. Dworak, H.A., Charles, M.A., Pellerano, L.B., Sink, H. Development (2001) [Pubmed]
  34. Induction of hepatocyte growth factor/scatter factor by fibroblast clustering directly promotes tumor cell invasiveness. Kankuri, E., Cholujova, D., Comajova, M., Vaheri, A., Bizik, J. Cancer Res. (2005) [Pubmed]
  35. Modulation by heparin of the interaction of the A1 domain of Von Willebrand factor with glycoprotein Ib. Perrault, C., Ajzenberg, N., Legendre, P., Rastegar-Lari, G., Meyer, D., Lopez, J.A., Baruch, D. Blood (1999) [Pubmed]
  36. Disruption of LRG1 inhibits mother-daughter separation in Saccharomyces cerevisiae. Svarovsky, M.J., Palecek, S.P. Yeast (2005) [Pubmed]
  37. The multistep process of homotypic neutrophil aggregation: a review of the molecules and effects of hydrodynamics. Simon, S.I., Neelamegham, S., Taylor, A., Smith, C.W. Cell Adhes. Commun. (1998) [Pubmed]
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