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Gene Review: 

Art4  -  ADP-ribosyltransferase 4

Mus musculus

Synonyms: 4432404K01Rik, ADP-ribosyltransferase C2 and C3 toxin-like 4, ARTC4, DO, DOK1, ...
 
 
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Disease relevance of Art4

  • The PTB domain of mouse dok1 fusion protein has been overexpressed in Escherichia coli and crystallized in a form suitable for X-ray crystallographic study [1].
 

High impact information on Art4

  • SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL [2].
  • A selenomethionine (SeMet) dok1 PTB fusion-protein derivative was expressed using the same expression system, purified in a reductive environment and crystals were obtained under similar conditions [1].
 

Analytical, diagnostic and therapeutic context of Art4

References

  1. Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of mouse dok1 protein. Shi, N., Liu, Y., Ni, M., Yang, M., Wu, J., Peng, Y., Gao, F., Sun, F., Peng, X., Qiang, B., Rao, Z., Yuan, J. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
  2. SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL. Sattler, M., Verma, S., Pride, Y.B., Salgia, R., Rohrschneider, L.R., Griffin, J.D. J. Biol. Chem. (2001) [Pubmed]
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