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Gene Review

Tpgs1  -  tubulin polyglutamylase complex subunit 1

Mus musculus

Synonyms: AV005629, Gm16517, Gtrgeo22, PGs1, Tubulin polyglutamylase complex subunit 1, ...
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High impact information on Gtrgeo22

  • Gtrgeo22 is expressed at low levels in epithelial cells in several tissues, as well as in testis and brain [1].
  • Analysis of the peptide coding sequence suggests that Gtrgeo22 encodes a novel transmembrane protein, which contains dileucine and tyrosine-based motifs involved in intracellular sorting of transmembrane proteins [1].
  • Analysis of the Gtrgeo22 gene product should provide novel insight into the molecular basis for intermale aggression and sperm flagellar development [1].


  1. Mutation of a novel gene results in abnormal development of spermatid flagella, loss of intermale aggression and reduced body fat in mice. Campbell, P.K., Waymire, K.G., Heier, R.L., Sharer, C., Day, D.E., Reimann, H., Jaje, J.M., Friedrich, G.A., Burmeister, M., Bartness, T.J., Russell, L.D., Young, L.J., Zimmer, M., Jenne, D.E., MacGregor, G.R. Genetics (2002) [Pubmed]
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