Gene Review:
Cxv1 - control of xenotropic virus 1
Mus musculus
Synonyms:
Cxv-1
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High impact information on Cxv1
- In crosses of F/St with AKR, the high-virus phenotype of F/St was found to be recessive and was shown to be governed by a single locus, Cxv-1, less than 2 centimorgans from H-2K [1].
- Studies of hybrid mice homozygous for Cxv-1s, but segregating for a chromosome 1 X-MuLV induction locus (V locus) of F/St, demonstrated that the high-virus phenotype of F/St was dependent on the interaction between Cxv-1 and the chromosome 1 V locus [1].
- The close association of Cxv-1 with the H-2 complex was confirmed by the observation that B10.F mice, congeneic for the H-2 region of F/St, expressed high levels of infectious X-MuLV and XenCSA, whereas C57BL/10 mice and other C57BL/10 H-2 congeneic strains did not [1].
References
- H-2-linked regulation of xenotropic murine leukemia virus expression. Yetter, R.A., Hartley, J.W., Morse, H.C. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
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