The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

H2-K1  -  histocompatibility 2, K1, K region

Mus musculus

Synonyms: H-2 class I histocompatibility antigen, K-B alpha chain, H-2 class I histocompatibility antigen, K-D alpha chain, H-2 class I histocompatibility antigen, K-K alpha chain, H-2 class I histocompatibility antigen, K-Q alpha chain, H-2 class I histocompatibility antigen, K-W28 alpha chain, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of H2-K1

  • Regulated expression of an introduced MHC H-2K bm1 gene in murine embryonal carcinoma cells [1].
  • Furthermore, CD4(+) T cells from CD1d(-/-) knockout (KO) B6 donor mice but not those from MHC-I(-/-) (homozygous transgenic mice deficient for beta(2)-microglobulin) KO B6 mice induced a colitis in RAG(-/-) hosts [2].
  • Recently, we reported the down-regulation of MHC class I (MHC-I) products in invading tumor cells in human and mouse GL261 gliomas [3].
  • Divergent effects of H-2K and H-2D genes on sensitivity of BL6 melanoma cells to NK cells or TNF-mediated cytotoxicity [4].
  • In a series of newly isolated AKR leukemias, some tumors expressed large amounts of both H-2K and H-2D molecules, while others had reduced levels of both antigens [5].

Psychiatry related information on H2-K1

  • We show that in primary spontaneous AKR leukemias, in spite of large individual differences, the expression of high amounts of MuLV gp70 is not random, but is associated with high expression of H-2K and H-2D antigens [6].

High impact information on H2-K1

  • Thus, this study characterizes the naturally occurring peptide moiety of an MHC-I/peptide complex recognized by alloreactive CD8+ T cells [7].
  • At the centromeric end the t12 lethal maps between TL and H-2D in the Qa region, and distally the tw5 lethal is inseparable from H-2K [8].
  • Our previous studies indicate that the Q10 gene is a potential donor gene for the generation of mutations at the H-2K locus by inter-gene transfer of genetic information [9].
  • Our findings suggest that the two sequences are derived from allelic class I genes, which are nonpolymorphic, in contrast to H-2K allelic sequences from the same mice, and they may encode liver-specific polypeptides of unknown function [9].
  • The hybrid H-2 K antigens were examined for their ability to function as restricting elements for cytotoxic T lymphocytes during influenza A infection [10].

Chemical compound and disease context of H2-K1


Biological context of H2-K1

  • The transplantation antigens H-2K, H-2D and H-2L are developmentally regulated, highly polymorphic cell surface proteins encoded by the major histocompatibility gene complex (MHC) [1].
  • One, Idd-1s, is tightly linked to the H-2K locus on chromosome 17; another, Idd-2s, is localized proximal to the Thy-1/Alp-1 cluster on chromosome 9 [14].
  • All CTL lines appear to be restricted in target cell recognition to either the H-2K or the H-2D end of the appropriate H-2 haplotype [15].
  • These findings confirm at the clonal level previous observations on the H-2K/D restriction of virus-specific CTL and also demonstrate heterogeneity among H-2 restricted CTL both from the standpoint of viral antigen recognition and cell surface phenotype [15].
  • We have searched for expressed genes in 170 kb of cosmid cloned DNA from the H-2K region of the mouse MHC [16].

Anatomical context of H2-K1


Associations of H2-K1 with chemical compounds


Physical interactions of H2-K1


Regulatory relationships of H2-K1

  • Establishment of T-cell clones recognizing difference in H-2K antigen and inducing graft-versus-host disease [29].
  • Comparison of H-2 antigens immunoprecipitated from normal spleen cells and from thioglycollate-induced adherent peritoneal exudate cells cultured in the presence or absence of supernatant fluids from concanavalin A-stimulated spleen cells revealed that H-2K' was not expressed on the adherent peritoneal cells [30].
  • These spleen cells displayed strong lysis on TNP-modified H-2D end-matched (Kd-Dk) targets as well as enhanced cytotoxicity against H-2 matched (Kk-Dk) or H-2K end-matched (Kk-Dd) target cells [31].
  • Transfection of non-expressor cells by v-fos or c-fos genes induces the transcription of H-2K mRNA and elevates the levels of H-2 proteins, but not of other gene products [32].

Other interactions of H2-K1

  • However, beta2m associates with a number of MHC-I-like proteins, including HFE [33].
  • In crosses of F/St with AKR, the high-virus phenotype of F/St was found to be recessive and was shown to be governed by a single locus, Cxv-1, less than 2 centimorgans from H-2K [34].
  • The basic relationship of H-2 K, D, L antigens is revealed also by the shared antigenic specificities between these H-2 molecules which we demonstrate using anti-H-2.28 sera [35].
  • TNF-alpha consistently up-regulates the expression of ICAM-1, but not H-2K, in a time- and dose-dependent manner [36].
  • IL-10 slightly but reproducibly inhibits the expression of ICAM-1, but not H-2K, in a time- and dose-dependent manner [36].

Analytical, diagnostic and therapeutic context of H2-K1


  1. Regulated expression of an introduced MHC H-2K bm1 gene in murine embryonal carcinoma cells. Rosenthal, A., Wright, S., Cedar, H., Flavell, R., Grosveld, F. Nature (1984) [Pubmed]
  2. MHC-II-independent CD4+ T cells induce colitis in immunodeficient RAG-/- hosts. Trobonjaca, Z., Leithäuser, F., Möller, P., Bluethmann, H., Koezuka, Y., MacDonald, H.R., Reimann, J. J. Immunol. (2001) [Pubmed]
  3. The combination of ionizing radiation and peripheral vaccination produces long-term survival of mice bearing established invasive GL261 gliomas. Newcomb, E.W., Demaria, S., Lukyanov, Y., Shao, Y., Schnee, T., Kawashima, N., Lan, L., Dewyngaert, J.K., Zagzag, D., McBride, W.H., Formenti, S.C. Clin. Cancer Res. (2006) [Pubmed]
  4. Divergent effects of H-2K and H-2D genes on sensitivity of BL6 melanoma cells to NK cells or TNF-mediated cytotoxicity. Kim, M., Duty, L., Herberman, R., Gorelik, E. Cell. Immunol. (1994) [Pubmed]
  5. Control of synthesis and expression of H-2 heavy chain and beta-2 microglobulin in AKR leukemias. Schmidt, W., Henseling, U., Bevec, D., Alonzo, A.D., Festenstein, H. Immunogenetics (1985) [Pubmed]
  6. Correlation between quantitative expression of H-2K, H-2D and MuLV antigens on spontaneous AKR lymphomas. Oudshoorn-Snoek, M., Demant, P. Int. J. Cancer (1986) [Pubmed]
  7. A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein. Udaka, K., Tsomides, T.J., Eisen, H.N. Cell (1992) [Pubmed]
  8. Gene mapping within the T/t complex of the mouse. IV: The inverted MHC is intermingled with several t-lethal genes. Shin, H.S., Bennett, D., Artzt, K. Cell (1984) [Pubmed]
  9. A nonpolymorphic class I gene in the murine major histocompatibility complex. Mellor, A.L., Weiss, E.H., Kress, M., Jay, G., Flavell, R.A. Cell (1984) [Pubmed]
  10. Cytolytic T cells recognize the two amino-terminal domains of H-2 K antigens in tandem in influenza A infected cells. Arnold, B., Burgert, H.G., Hamann, U., Hämmerling, G., Kees, U., Kvist, S. Cell (1984) [Pubmed]
  11. Crystal structure of the murine cytomegalovirus MHC-I homolog m144. Natarajan, K., Hicks, A., Mans, J., Robinson, H., Guan, R., Mariuzza, R.A., Margulies, D.H. J. Mol. Biol. (2006) [Pubmed]
  12. Indomethacin-induced sialic acid-mediated changes in surface markers from "cortical type" to "medullary type" in murine thymoma line EL-4. Tomooka, S., Serushago, B.A., Koga, Y., Taniguchi, K., Nomoto, K. Immunobiology (1986) [Pubmed]
  13. Cyclosporine blocks the induction of class I and class II MHC products in mouse kidney by graft-vs-host disease. Autenried, P., Halloran, P.F. J. Immunol. (1985) [Pubmed]
  14. Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice. Prochazka, M., Leiter, E.H., Serreze, D.V., Coleman, D.L. Science (1987) [Pubmed]
  15. Heterogeneity and specificity of cloned lines of influenza-virus specific cytotoxic T lymphocytes. Braciale, T.J., Andrew, M.E., Braciale, V.L. J. Exp. Med. (1981) [Pubmed]
  16. Searching for coding sequences in the mammalian genome: the H-2K region of the mouse MHC is replete with genes expressed in embryos. Abe, K., Wei, J.F., Wei, F.S., Hsu, Y.C., Uehara, H., Artzt, K., Bennett, D. EMBO J. (1988) [Pubmed]
  17. H-2-restricted helper factor secreted by clone hybridoma cells. Lonai, P., Puri, J., Bitton, S., Ben-Neriah, Y., Givol, D., Hämmerling, G.J. J. Exp. Med. (1981) [Pubmed]
  18. Major histocompatibility complex (MHC) class I KbDb -/- deficient mice possess functional CD8+ T cells and natural killer cells. Vugmeyster, Y., Glas, R., Pérarnau, B., Lemonnier, F.A., Eisen, H., Ploegh, H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  19. Influence of xenogeneic beta2-microglobulin on functional recognition of H-2Kb by the NK cell inhibitory receptor Ly49C. Benoit, L.A., Shannon, J., Chamberlain, J.W., Miller, R.G. J. Immunol. (2005) [Pubmed]
  20. Molecular analysis of deficient class I H-2 antigen expression by mouse lung carcinoma cells. Bahler, D.W., Cerosaletti, K.M., Lord, E.M., Frelinger, J.G. J. Immunol. (1988) [Pubmed]
  21. Helper cells activated by allogeneic H-2K or H-2D differences have a Ly phenotype distinct from those responsive to I differences. Swain, S.L., Panfili, P.R. J. Immunol. (1979) [Pubmed]
  22. Multiple Residues in the Transmembrane Helix and Connecting Peptide of Mouse Tapasin Stabilize the Transporter Associated with the Antigen-processing TAP2 Subunit. Papadopoulos, M., Momburg, F. J. Biol. Chem. (2007) [Pubmed]
  23. Influence of asparagine-linked oligosaccharides on tumor cell recognition in the mixed lymphocyte reaction. Powell, L.D., Bause, E., Legler, G., Molyneux, R.J., Hart, G.W. J. Immunol. (1985) [Pubmed]
  24. Regulation of MHC class I membrane expression by beta 2-microglobulin. Abdel Motal, U.M., Zhou, M.X., Siddiqi, A.R., Jondal, M. Scand. J. Immunol. (1993) [Pubmed]
  25. Regulation of T-cell-mediated lympholysis by the murine major histocompatibility complex. II. Control of cytotoxic responses to trinitrophenyl-K and -D self products by H-2K- and H-2D-Region genes. Levy, R.B., Shearer, G.M. J. Exp. Med. (1980) [Pubmed]
  26. Soluble factors in tolerance and contact sensitivity to 2,4-dinitrofluorobenzene in mice. III. Histocompatibility antigens associated with the hapten dinitrophenol serve as target molecules on 2,4-dinitrofluorobenzene-immune T cells for soluble suppressor factor. Moorhead, J.W. J. Exp. Med. (1979) [Pubmed]
  27. Interactions of Ly49 Family Receptors with MHC Class I Ligands in trans and cis. Scarpellino, L., Oeschger, F., Guillaume, P., Coudert, J.D., Lévy, F., Leclercq, G., Held, W. J. Immunol. (2007) [Pubmed]
  28. The murine liver-specific nonclassical MHC class I molecule Q10 binds a classical peptide repertoire. Zappacosta, F., Tabaczewski, P., Parker, K.C., Coligan, J.E., Stroynowski, I. J. Immunol. (2000) [Pubmed]
  29. Establishment of T-cell clones recognizing difference in H-2K antigen and inducing graft-versus-host disease. Watanabe, H., Fujiwara, M., Nishiyama, T., Ito, M., Mashiko, T., Nisizawa, T. Cell. Immunol. (1985) [Pubmed]
  30. Identification of a second class I antigen controlled by the K end of the H-2 complex and its selective cellular expression. Tryphonas, M., King, D.P., Jones, P.P. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  31. Detection of shared H-2Kk and H-2Dk antigens that function as self determinants for cell-mediated lympholysis to trinitrophenyl-self. Fujiwara, H., Levy, R.B., Shearer, G.M. J. Immunol. (1981) [Pubmed]
  32. The c-fos proto-oncogene in murine 3LL carcinoma clones controls the expression of MHC genes. Kushtai, G., Barzilay, J., Feldman, M., Eisenbach, L. Oncogene (1988) [Pubmed]
  33. Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis. Schaible, U.E., Collins, H.L., Priem, F., Kaufmann, S.H. J. Exp. Med. (2002) [Pubmed]
  34. H-2-linked regulation of xenotropic murine leukemia virus expression. Yetter, R.A., Hartley, J.W., Morse, H.C. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  35. Molecular heterogeneity of H-2 antigens. Démant, P., Iványi, D., Oudshoorn-Snoek, M., Calafat, J., Roos, M.H. Immunol. Rev. (1981) [Pubmed]
  36. Selective regulation of ICAM-1 and major histocompatibility complex class I and II molecule expression on epidermal Langerhans cells by some of the cytokines released by keratinocytes and T cells. Chang, C.H., Furue, M., Tamaki, K. Eur. J. Immunol. (1994) [Pubmed]
  37. Exon shuffling: mapping polymorphic determinants on hybrid mouse transplantation antigens. Evans, G.A., Margulies, D.H., Shykind, B., Seidman, J.G., Ozato, K. Nature (1982) [Pubmed]
WikiGenes - Universities