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Gene Review

nifH2  -  nitrogenase reductase

Nostoc sp. PCC 7120

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Disease relevance of nifH2

  • The heterocystous cyanobacterium Nostoc commune UTEX 584 contains two nifH-like sequences (nifH1 and nifH2) in addition to nifHD [1].
  • Sequencing of a segment of the nitrogenase reductase gene (nifH) indicated that Chroococcidiopsis possesses the alternative molybdenum nitrogenase 2, expressed in Anabaena variabilis only under reduced O2 tensions, rather than the widespread, common molybdenum nitrogenase [2].


  1. Cloning of nifHD from Nostoc commune UTEX 584 and of a flanking region homologous to part of the Azotobacter vinelandii nifU gene. Defrancesco, N., Potts, M. J. Bacteriol. (1988) [Pubmed]
  2. Bacterial life and dinitrogen fixation at a gypsum rock. Boison, G., Mergel, A., Jolkver, H., Bothe, H. Appl. Environ. Microbiol. (2004) [Pubmed]
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