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Gene Review:

Iglv2 - immunoglobulin lambda variable 2

Mus musculus

Synonyms: Igl-V2

Aguilar, B.A. et al., Snodgrass, H.R. et al.

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High impact information on Igl-V2

We have sequenced the T cell receptor (TcR) V alpha and V beta genes of seven independent BALB/c CD4+ T cell clones specific for the immunoglobulin lambda 2 light chain produced by the MOPC 315 myeloma (lambda 2(315)) [1].
At least two of these sub-families, Igl-V2 and Igl-V3, contain multiple members as well as restriction fragment length polymorphism variants, indicating the presence of at least 10-15 Igl-V gene segments (including some pseudogenes) in the rat genome [2].

References

Restricted alpha/beta receptor gene usage of idiotype-specific major histocompatibility complex-restricted T cells: selection for CDR3-related sequences. Snodgrass, H.R., Fisher, A.M., Bruyns, E., Bogen, B. Eur. J. Immunol. (1992) [Pubmed]
Transcription and diversity of immunoglobulin lambda chain variable genes in the rat. Aguilar, B.A., Gutman, G.A. Immunogenetics (1992) [Pubmed]

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