The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

Idd13  -  insulin dependent diabetes susceptibility 13

Mus musculus

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Idd13

  • We report that NOD-derived alleles at both the Idd5 and Idd13 loci regulate a T lymphocyte-dependent progression from a benign to a destructive stage of insulitis [1].
  • The second most significant locus (Nkt2) mapped to the same region as Idd13, a NOD-derived diabetes susceptibility gene on chromosome 2 [2].
  • Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin [3].
 

Biological context of Idd13

  • NOD stocks carrying subcongenic intervals of NOR Chromosome 2 were utilized to more finely map and determine possible functions of Idd13 [3].

References

  1. Two genetic loci regulate T cell-dependent islet inflammation and drive autoimmune diabetes pathogenesis. Fox, C.J., Paterson, A.D., Mortin-Toth, S.M., Danska, J.S. Am. J. Hum. Genet. (2000) [Pubmed]
  2. Genetic control of NKT cell numbers maps to major diabetes and lupus loci. Esteban, L.M., Tsoutsman, T., Jordan, M.A., Roach, D., Poulton, L.D., Brooks, A., Naidenko, O.V., Sidobre, S., Godfrey, D.I., Baxter, A.G. J. Immunol. (2003) [Pubmed]
  3. Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin. Serreze, D.V., Bridgett, M., Chapman, H.D., Chen, E., Richard, S.D., Leiter, E.H. J. Immunol. (1998) [Pubmed]
 
WikiGenes - Universities