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Gene Review

Idd17  -  insulin dependent diabetes susceptibility 17

Mus musculus

 
 
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High impact information on Idd17

  • Interestingly, although Idd10 and Idd17 participate in a genetic interaction with each other, Idd10 but not Idd17 participates in the genetic interaction with Idd3 [1].
  • Thus, Fcgr1 was excluded as a candidate for either Idd10 or Idd17, despite the fact that the NOD strain expresses a mutant form of the receptor [1].
  • Previously, three insulin-dependent diabetes (Idd) genes, Idd3, Idd10, and Idd17, were localized to mouse Chromosome (Chr) 3 [2].

References

  1. Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1. Podolin, P.L., Denny, P., Lord, C.J., Hill, N.J., Todd, J.A., Peterson, L.B., Wicker, L.S., Lyons, P.A. J. Immunol. (1997) [Pubmed]
  2. Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse chromosome 3. Podolin, P.L., Denny, P., Armitage, N., Lord, C.J., Hill, N.J., Levy, E.R., Peterson, L.B., Todd, J.A., Wicker, L.S., Lyons, P.A. Mamm. Genome (1998) [Pubmed]
 
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