The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Fcgr1  -  Fc receptor, IgG, high affinity I

Mus musculus

Synonyms: AI323638, AV092959, CD64, Fc-gamma RI, FcRI, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Fcgr1


Psychiatry related information on Fcgr1

  • These results demonstrate that CD64-recruited cytotoxic effectors operate in vivo but that the (huCD64 x Id) conferred an additional anti-tumor function essential for long-term protection [5].
  • We found Fc gamma RI, II and III immunoreactivity in senile plaques and on ramified microglia throughout the cortex and white matter of normal and Alzheimer's disease brains [6].

High impact information on Fcgr1

  • The gamma subunit of immunoglobulin Fc receptors is an essential component of the high-affinity receptor for IgG (Fc gamma RIII) and is associated with the high-affinity receptor for IgG (Fc gamma RI) and the T cell receptor-CD3 complex [7].
  • A fully penetrant immunological defect also mapped to this segment, which encodes the high-affinity Fc receptor for immunoglobulin G (IgG), Fc gamma RI [8].
  • Transfer of FcRI-expressing basophils into FcRI-deficient mice restored the development of the delayed-onset allergic inflammation [9].
  • By using a variety of FcgammaR(-/-) mice, we demonstrate that in the absence of FcgammaRI, the IgG2a-IC-induced cellular processes of phagocytosis, cytokine release, cellular cytotoxicity, and antigen presentation are impaired [1].
  • In addition, FcR-gamma chain-deficient mice were found to express partially functional FcgammaRI [10].

Biological context of Fcgr1


Anatomical context of Fcgr1


Associations of Fcgr1 with chemical compounds


Physical interactions of Fcgr1

  • Furthermore, HCC49x H22 was shown to simultaneously bind to KLEB cells and a soluble FcgammaRI fusion protein, demonstrating the bifunctional nature of the molecule [21].
  • Because of mutations in the Fc gamma RI and C'1q binding sites of the Fc portion of the murine CTLA4/Fc fusion protein, the molecule binds to, but does not target, cells for Ab-dependent cellular cytotoxicity or complement-directed cytolysis [22].

Regulatory relationships of Fcgr1


Other interactions of Fcgr1

  • The high-affinity receptor for IgG, FcgammaRI, shares its capacity to bind IgG2a immune complexes (IgG2a-IC) with the low-affinity receptor FcgammaRIII and complement factors, hampering the definition of its biological role [1].
  • Induction of intracellular Ca2+ mobilization and cytotoxicity by hybrid mouse monoclonal antibodies. Fc gamma RII regulation of Fc gamma RI-triggered functions or signaling [26]?
  • FcgammaRI up-regulation induced by local adenoviral-mediated interferon-gamma production aggravates chondrocyte death during immune complex-mediated arthritis [13].
  • In a previous study we found that if a chronic T-cell-mediated antigen-induced arthritis (AIA) was elicited in knee joints of FcR gamma-chain-deficient mice that lack functional Fc gamma RI and Fc gamma RIII, joint inflammation was comparable but severe cartilage destruction was absent [27].
  • In this paper, we demonstrate that, in response to IgG immune complex formation, FcgammaRI/III- and C5aR-mediated pathways are both necessary and only together are they sufficient to trigger the full expression of inflammation in skin and lung [2].

Analytical, diagnostic and therapeutic context of Fcgr1


  1. FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Ioan-Facsinay, A., de Kimpe, S.J., Hellwig, S.M., van Lent, P.L., Hofhuis, F.M., van Ojik, H.H., Sedlik, C., da Silveira, S.A., Gerber, J., de Jong, Y.F., Roozendaal, R., Aarden, L.A., van den Berg, W.B., Saito, T., Mosser, D., Amigorena, S., Izui, S., van Ommen, G.J., van Vugt, M., van de Winkel, J.G., Verbeek, J.S. Immunity (2002) [Pubmed]
  2. A codominant role of Fc gamma RI/III and C5aR in the reverse Arthus reaction. Baumann, U., Köhl, J., Tschernig, T., Schwerter-Strumpf, K., Verbeek, J.S., Schmidt, R.E., Gessner, J.E. J. Immunol. (2000) [Pubmed]
  3. Antibody dependent cellular phagocytosis (ADCP) and antibody dependent cellular cytotoxicity (ADCC) of breast cancer cells mediated by bispecific antibody, MDX-210. Watanabe, M., Wallace, P.K., Keler, T., Deo, Y.M., Akewanlop, C., Hayes, D.F. Breast Cancer Res. Treat. (1999) [Pubmed]
  4. The high-affinity IgG receptor, FcgammaRI, plays a central role in antibody therapy of experimental melanoma. Bevaart, L., Jansen, M.J., van Vugt, M.J., Verbeek, J.S., van de Winkel, J.G., Leusen, J.H. Cancer Res. (2006) [Pubmed]
  5. Therapeutic efficacy of FcgammaRI/CD64-directed bispecific antibodies in B-cell lymphoma. Honeychurch, J., Tutt, A.L., Valerius, T., Heijnen, I.A., Van De Winkel, J.G., Glennie, M.J. Blood (2000) [Pubmed]
  6. Identification of Fc gamma RI, II and III on normal human brain ramified microglia and on microglia in senile plaques in Alzheimer's disease. Peress, N.S., Fleit, H.B., Perillo, E., Kuljis, R., Pezzullo, C. J. Neuroimmunol. (1993) [Pubmed]
  7. FcR gamma chain deletion results in pleiotrophic effector cell defects. Takai, T., Li, M., Sylvestre, D., Clynes, R., Ravetch, J.V. Cell (1994) [Pubmed]
  8. Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice. Prins, J.B., Todd, J.A., Rodrigues, N.R., Ghosh, S., Hogarth, P.M., Wicker, L.S., Gaffney, E., Podolin, P.L., Fischer, P.A., Sirotina, A. Science (1993) [Pubmed]
  9. Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Mukai, K., Matsuoka, K., Taya, C., Suzuki, H., Yokozeki, H., Nishioka, K., Hirokawa, K., Etori, M., Yamashita, M., Kubota, T., Minegishi, Y., Yonekawa, H., Karasuyama, H. Immunity (2005) [Pubmed]
  10. FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses. Barnes, N., Gavin, A.L., Tan, P.S., Mottram, P., Koentgen, F., Hogarth, P.M. Immunity (2002) [Pubmed]
  11. Evidence for Cd101 but not Fcgr1 as candidate for type 1 diabetes locus, Idd10. Yamaji, K., Ikegami, H., Fujisawa, T., Noso, S., Nojima, K., Babaya, N., Itoi-Babaya, M., Makino, S., Sakamoto, T., Ogihara, T. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  12. Antigen targeting to myeloid-specific human Fc gamma RI/CD64 triggers enhanced antibody responses in transgenic mice. Heijnen, I.A., van Vugt, M.J., Fanger, N.A., Graziano, R.F., de Wit, T.P., Hofhuis, F.M., Guyre, P.M., Capel, P.J., Verbeek, J.S., van de Winkel, J.G. J. Clin. Invest. (1996) [Pubmed]
  13. FcgammaRI up-regulation induced by local adenoviral-mediated interferon-gamma production aggravates chondrocyte death during immune complex-mediated arthritis. Nabbe, K.C., van Lent, P.L., Holthuysen, A.E., Kolls, J.K., Verbeek, S., van den Berg, W.B. Am. J. Pathol. (2003) [Pubmed]
  14. Structure and mapping of the gene encoding mouse high affinity Fc gamma RI and chromosomal location of the human Fc gamma RI gene. Osman, N., Kozak, C.A., McKenzie, I.F., Hogarth, P.M. J. Immunol. (1992) [Pubmed]
  15. Characterization of IgG FcR-mediated proliferation of human T cells induced by mouse and human anti-CD3 monoclonal antibodies. Identification of a functional polymorphism to human IgG2 anti-CD3. Parren, P.W., Warmerdam, P.A., Boeije, L.C., Capel, P.J., van de Winkel, J.G., Aarden, L.A. J. Immunol. (1992) [Pubmed]
  16. Fc gamma RI and Fc gamma RII on monocytes and granulocytes are cytotoxic trigger molecules for tumor cells. Graziano, R.F., Fanger, M.W. J. Immunol. (1987) [Pubmed]
  17. Differential effects of interferon-gamma and glucocorticoids on Fc gamma R gene expression in murine macrophages. Sivo, J., Politis, A.D., Vogel, S.N. J. Leukoc. Biol. (1993) [Pubmed]
  18. Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis. Huang, Z.Y., Barreda, D.R., Worth, R.G., Indik, Z.K., Kim, M.K., Chien, P., Schreiber, A.D. J. Leukoc. Biol. (2006) [Pubmed]
  19. Intracluster restriction of Fc receptor gamma-chain tyrosine phosphorylation subverted by a protein-tyrosine phosphatase inhibitor. Pfefferkorn, L.C., Swink, S.L. J. Biol. Chem. (1996) [Pubmed]
  20. Molecular cloning and expression of the mouse high affinity Fc receptor for IgG. Sears, D.W., Osman, N., Tate, B., McKenzie, I.F., Hogarth, P.M. J. Immunol. (1990) [Pubmed]
  21. Characterization of a novel bispecific antibody that mediates Fcgamma receptor type I-dependent killing of tumor-associated glycoprotein-72-expressing tumor cells. Russoniello, C., Somasundaram, C., Schlom, J., Deo, Y.M., Keler, T. Clin. Cancer Res. (1998) [Pubmed]
  22. Ex vivo coating of islet cell allografts with murine CTLA4/Fc promotes graft tolerance. Steurer, W., Nickerson, P.W., Steele, A.W., Steiger, J., Zheng, X.X., Strom, T.B. J. Immunol. (1995) [Pubmed]
  23. Regulated expression and inhibitory function of Fcgamma RIIb in human monocytic cells. Tridandapani, S., Siefker, K., Teillaud, J.L., Carter, J.E., Wewers, M.D., Anderson, C.L. J. Biol. Chem. (2002) [Pubmed]
  24. Fcgamma receptor deficiency confers protection against atherosclerosis in apolipoprotein E knockout mice. Hern??ndez-Vargas, P., Ortiz-Mu??oz, G., L??pez-Franco, O., Suzuki, Y., Gallego-Delgado, J., Sanju??n, G., L??zaro, A., L??pez-Parra, V., Ortega, L., Egido, J., G??mez-Guerrero, C. Circ. Res. (2006) [Pubmed]
  25. FcgammaRIII (CD16)-deficient mice show IgG isotype-dependent protection to experimental autoimmune hemolytic anemia. Meyer, D., Schiller, C., Westermann, J., Izui, S., Hazenbos, W.L., Verbeek, J.S., Schmidt, R.E., Gessner, J.E. Blood (1998) [Pubmed]
  26. Induction of intracellular Ca2+ mobilization and cytotoxicity by hybrid mouse monoclonal antibodies. Fc gamma RII regulation of Fc gamma RI-triggered functions or signaling? Koolwijk, P., Van de Winkel, J.G., Pfefferkorn, L.C., Jacobs, C.W., Otten, I., Spierenburg, G.T., Bast, B.J. J. Immunol. (1991) [Pubmed]
  27. Role of activatory Fc gamma RI and Fc gamma RIII and inhibitory Fc gamma RII in inflammation and cartilage destruction during experimental antigen-induced arthritis. van Lent, P.L., Nabbe, K., Blom, A.B., Holthuysen, A.E., Sloetjes, A., van de Putte, L.B., Verbeek, S., van den Berg, W.B. Am. J. Pathol. (2001) [Pubmed]
  28. Central role of complement in passive protection by human IgG1 and IgG2 anti-pneumococcal antibodies in mice. Saeland, E., Vidarsson, G., Leusen, J.H., Van Garderen, E., Nahm, M.H., Vile-Weekhout, H., Walraven, V., Stemerding, A.M., Verbeek, J.S., Rijkers, G.T., Kuis, W., Sanders, E.A., Van De Winkel, J.G. J. Immunol. (2003) [Pubmed]
  29. Fc gamma receptors play a dominant role in protective tumor immunity against a virus-encoded tumor-specific antigen in a murine model of experimental pulmonary metastases. Lowe, D.B., Shearer, M.H., Jumper, C.A., Bright, R.K., Kennedy, R.C. J. Virol. (2007) [Pubmed]
  30. Interferon-gamma antagonizes interleukin-6-induced expression of interleukin-4 receptors in murine myeloid cells by a transcriptional mechanism. Ruhl, S., Feldman, G.M., Akahane, K., Pluznik, D.H. Blood (1993) [Pubmed]
  31. Reversal of proinflammatory responses by ligating the macrophage Fcgamma receptor type I. Sutterwala, F.S., Noel, G.J., Salgame, P., Mosser, D.M. J. Exp. Med. (1998) [Pubmed]
WikiGenes - Universities