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Gene Review:

Sle1a - systematic lupus erythematosus...

Mus musculus

Chen, Y. et al., Morel, L. et al., Croker, B.P. et al.

Morel, Blenman, Croker, Wakeland,

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High impact information on Sle1a

Each displays a distinctive profile of serological and cellular characteristics, with T and B cell functions being more affected by Sle1a and Sle1b, respectively [1].
The Sle1a locus alone accounts for all these Sle1 phenotypes, implying that a specific genetic defect in Sle1a is necessary and sufficient to produce autoreactive T cells [2].
Moreover, Sle1a and Sle1c were associated with a significantly reduced level of CD4(+)CD25(+) regulatory T cells that precedes autoantibody production, suggesting a causal relationship with the generation of autoreactive T cells [2].

Other interactions of Sle1a

This suggests a major role for the FAS pathway in keeping in check the loss of tolerance mediated by the Sle1 loci, especially for Sle1a [3].

References

The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Morel, L., Blenman, K.R., Croker, B.P., Wakeland, E.K. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
Genetic determination of T cell help in loss of tolerance to nuclear antigens. Chen, Y., Cuda, C., Morel, L. J. Immunol. (2005) [Pubmed]
Genetic interactions between susceptibility loci reveal epistatic pathogenic networks in murine lupus. Croker, B.P., Gilkeson, G., Morel, L. Genes Immun. (2003) [Pubmed]

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