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MeSH Review

T-Lymphocytes, Regulatory

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Disease relevance of T-Lymphocytes, Regulatory


High impact information on T-Lymphocytes, Regulatory

  • Lack of Foxp3 leads to development of fatal autoimmune lymphoproliferative disease; furthermore, ectopic Foxp3 expression can phenotypically convert effector T cells to regulatory T cells [6].
  • The role of MHC products in the induction of suppressor cells has several homologies with the mechanisms responsible for the induction of H-2-restricted helper cells [7].
  • The NP and ABA suppressor-cell pathways consist of multiple cellular elements, including at least three and possibly four distinct T-cell populations and two or more distinctive accessory cell populations [7].
  • Abnormal histamine-induced suppressor-cell function in atopic subjects [8].
  • Thus, there is loss of peripheral suppressor cells in many patients with active MS, suggesting that immunoregulatory abnormalities contribute to the pathogenesis of the disease [9].

Chemical compound and disease context of T-Lymphocytes, Regulatory


Biological context of T-Lymphocytes, Regulatory


Anatomical context of T-Lymphocytes, Regulatory


Associations of T-Lymphocytes, Regulatory with chemical compounds


Gene context of T-Lymphocytes, Regulatory

  • We demonstrate that the cellular mechanism by which Aire exerts its tolerance-promoting function is not primarily positive selection of regulatory T cells, but rather negative selection of T effector cells [30].
  • A function for interleukin 2 in Foxp3-expressing regulatory T cells [31].
  • Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells [32].
  • Here, we determined the chemotactic response profile and chemokine receptor expression of human blood-borne CD4(+)CD25(+) Treg cells [33].
  • FasL-deficient mice exposed to UV lack both transferable suppressor cell activity and primary suppression to all antigens tested, with the exception of the DTH response to allogeneic spleen cells [34].

Analytical, diagnostic and therapeutic context of T-Lymphocytes, Regulatory


  1. Modulation of suppressor-cell activity by cimetidine in patients with common variable hypogammaglobulinemia. White, W.B., Ballow, M. N. Engl. J. Med. (1985) [Pubmed]
  2. Prostaglandin-producing suppressor cells in Hodgkin's disease. Goodwin, J.S., Messner, R.P., Bankhurst, A.D., Peake, G.T., Saiki, J.H., Williams, R.C. N. Engl. J. Med. (1977) [Pubmed]
  3. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Shimizu, J., Yamazaki, S., Takahashi, T., Ishida, Y., Sakaguchi, S. Nat. Immunol. (2002) [Pubmed]
  4. The role of I-J and Igh determinants on F1-derived suppressor factor in controlling restriction specificity. Minami, M., Aoki, I., Honji, N., Waltenbaugh, C.R., Dorf, M.E. J. Exp. Med. (1983) [Pubmed]
  5. Antigen- and receptor-driven regulatory mechanisms. VIII. Suppression of idiotype-negative, p-azobenzenearsonate-specific T cells results from the interaction of an anti-idiotypic second-order T suppressor cell with a cross-reactive-idiotype-positive, p-azobenzenearsonate-primed T cell target. Sy, M.S., Nisonoff, A., Germain, R.N., Benacerraf, B., Greene, M.I. J. Exp. Med. (1981) [Pubmed]
  6. FOXP3: Of Mice and Men. Ziegler, S.F. Annu. Rev. Immunol. (2006) [Pubmed]
  7. Suppressor cells and immunoregulation. Dorf, M.E., Benacerraf, B. Annu. Rev. Immunol. (1984) [Pubmed]
  8. Abnormal histamine-induced suppressor-cell function in atopic subjects. Beer, D.J., Osband, M.E., McCaffrey, R.P., Soter, N.A., Rocklin, R.E. N. Engl. J. Med. (1982) [Pubmed]
  9. Loss of suppressor T cells in active multiple sclerosis. Analysis with monoclonal antibodies. Reinherz, E.L., Weiner, H.L., Hauser, S.L., Cohen, J.A., Distaso, J.A., Schlossman, S.F. N. Engl. J. Med. (1980) [Pubmed]
  10. Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy. Karlsson, M.R., Rugtveit, J., Brandtzaeg, P. J. Exp. Med. (2004) [Pubmed]
  11. Immunologic studies in asymptomatic hemophilia patients. Relationship to acquired immune deficiency syndrome (AIDS). Landay, A., Poon, M.C., Abo, T., Stagno, S., Lurie, A., Cooper, M.D. J. Clin. Invest. (1983) [Pubmed]
  12. NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. Fiorucci, S., Antonelli, E., Distrutti, E., Del Soldato, P., Flower, R.J., Clark, M.J., Morelli, A., Perretti, M., Ignarro, L.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  13. Effects of fish oil and corn oil diets on prostaglandin-dependent and myelopoiesis-associated immune suppressor mechanisms of mice bearing metastatic Lewis lung carcinoma tumors. Young, M.R., Young, M.E. Cancer Res. (1989) [Pubmed]
  14. The role of suppressor cells in the induction of murine photoallergic contact dermatitis and in its suppression by prior UVB irradiation. Granstein, R.D., Morison, W.L., Kripke, M.L. J. Immunol. (1983) [Pubmed]
  15. Induction of regulatory T-lymphocyte responses by liposomes carrying major histocompatibility complex molecules and foreign antigen. Walden, P., Nagy, Z.A., Klein, J. Nature (1985) [Pubmed]
  16. Protein microarrays for multiplex analysis of signal transduction pathways. Chan, S.M., Ermann, J., Su, L., Fathman, C.G., Utz, P.J. Nat. Med. (2004) [Pubmed]
  17. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Malek, T.R., Yu, A., Vincek, V., Scibelli, P., Kong, L. Immunity (2002) [Pubmed]
  18. Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection. Walther, M., Tongren, J.E., Andrews, L., Korbel, D., King, E., Fletcher, H., Andersen, R.F., Bejon, P., Thompson, F., Dunachie, S.J., Edele, F., de Souza, J.B., Sinden, R.E., Gilbert, S.C., Riley, E.M., Hill, A.V. Immunity (2005) [Pubmed]
  19. CD4+CD25+ regulatory T cells suppress allograft rejection mediated by memory CD8+ T cells via a CD30-dependent mechanism. Dai, Z., Li, Q., Wang, Y., Gao, G., Diggs, L.S., Tellides, G., Lakkis, F.G. J. Clin. Invest. (2004) [Pubmed]
  20. Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes. Sharif, S., Arreaza, G.A., Zucker, P., Mi, Q.S., Sondhi, J., Naidenko, O.V., Kronenberg, M., Koezuka, Y., Delovitch, T.L., Gombert, J.M., Leite-De-Moraes, M., Gouarin, C., Zhu, R., Hameg, A., Nakayama, T., Taniguchi, M., Lepault, F., Lehuen, A., Bach, J.F., Herbelin, A. Nat. Med. (2001) [Pubmed]
  21. Lithium: a modulator of cyclic AMP-dependent events in lymphocytes? Gelfand, E.W., Dosch, H.M., Hastings, B., Shore, A. Science (1979) [Pubmed]
  22. B cells and professional APCs recruit regulatory T cells via CCL4. Bystry, R.S., Aluvihare, V., Welch, K.A., Kallikourdis, M., Betz, A.G. Nat. Immunol. (2001) [Pubmed]
  23. Cells in bone marrow and in T cell colonies grown from bone marrow can suppress generation of cytotoxic T lymphocytes directed against their self antigens. Muraoka, S., Miller, R.G. J. Exp. Med. (1980) [Pubmed]
  24. Mechanisms of genetic resistance to Friend virus leukemia. III. Susceptibility of mitogen-responsive lymphocytes mediated by T cells. Kumar, V., Caruso, T., Bennett, M. J. Exp. Med. (1976) [Pubmed]
  25. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Akbari, O., Freeman, G.J., Meyer, E.H., Greenfield, E.A., Chang, T.T., Sharpe, A.H., Berry, G., DeKruyff, R.H., Umetsu, D.T. Nat. Med. (2002) [Pubmed]
  26. Modulation of tryptophan catabolism by regulatory T cells. Fallarino, F., Grohmann, U., Hwang, K.W., Orabona, C., Vacca, C., Bianchi, R., Belladonna, M.L., Fioretti, M.C., Alegre, M.L., Puccetti, P. Nat. Immunol. (2003) [Pubmed]
  27. Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. V. Role of idiotypes in the suppressor pathway. Weinberger, J.Z., Germain, R.N., Benacerraf, B., Dorf, M.E. J. Exp. Med. (1980) [Pubmed]
  28. Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell. Goodwin, J.S., Bankhurst, A.D., Messner, R.P. J. Exp. Med. (1977) [Pubmed]
  29. Specific suppression of allograft rejection by trinitrophenyl (TNP)-induced suppressor cells in recipients treated with TNP-haptenated donor alloantigens. Hutchinson, I.V., Barber, W.H., Morris, P.J. J. Exp. Med. (1985) [Pubmed]
  30. The cellular mechanism of Aire control of T cell tolerance. Anderson, M.S., Venanzi, E.S., Chen, Z., Berzins, S.P., Benoist, C., Mathis, D. Immunity (2005) [Pubmed]
  31. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Fontenot, J.D., Rasmussen, J.P., Gavin, M.A., Rudensky, A.Y. Nat. Immunol. (2005) [Pubmed]
  32. Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells. Levings, M.K., Sangregorio, R., Sartirana, C., Moschin, A.L., Battaglia, M., Orban, P.C., Roncarolo, M.G. J. Exp. Med. (2002) [Pubmed]
  33. Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. Iellem, A., Mariani, M., Lang, R., Recalde, H., Panina-Bordignon, P., Sinigaglia, F., D'Ambrosio, D. J. Exp. Med. (2001) [Pubmed]
  34. A critical role for Fas ligand in the active suppression of systemic immune responses by ultraviolet radiation. Hill, L.L., Shreedhar, V.K., Kripke, M.L., Owen-Schaub, L.B. J. Exp. Med. (1999) [Pubmed]
  35. Lentil lectin effectively induces allotransplantation tolerance in mice. Hilgert, I., Horejsí, V., Angelisová, P., Kristofová, H. Nature (1980) [Pubmed]
  36. Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. Gilliet, M., Liu, Y.J. J. Exp. Med. (2002) [Pubmed]
  37. Mechanisms of regulation of cell-mediated immunity. VII. Suppressor T cells induced by suboptimal doses of antigen plus an I-J-specific allogeneic effect. Bromberg, J.S., Benacerraf, B., Greene, M.I. J. Exp. Med. (1981) [Pubmed]
  38. Suppression of allergic airway inflammation by helminth-induced regulatory T cells. Wilson, M.S., Taylor, M.D., Balic, A., Finney, C.A., Lamb, J.R., Maizels, R.M. J. Exp. Med. (2005) [Pubmed]
  39. Idiopathic cardiomyopathy, age, and suppressor-cell dysfunction as risk determinants of lymphoma after cardiac transplantation. Anderson, J.L., Fowles, R.E., Bieber, C.P., Stinson, E.B. Lancet (1978) [Pubmed]
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