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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SORCS1  -  sortilin-related VPS10 domain containing...

Homo sapiens

Synonyms: SORCS, VPS10 domain-containing receptor SorCS1, hSorCS, sorCS1
 
 
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High impact information on SORCS1

  • Mature sorCS1 bound its own propeptide with low affinity but none of the ligands previously shown to interact with sortilin and sorLA [1].
  • We previously isolated and sequenced murine sorCS1, a type 1 receptor containing a Vps10p-domain and a leucine-rich domain [1].
  • In addition, PDGF-BB also bound to the luminal domains of sorCS1 and sorCS3 [2].

References

  1. Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells. Hermey, G., Keat, S.J., Madsen, P., Jacobsen, C., Petersen, C.M., Gliemann, J. J. Biol. Chem. (2003) [Pubmed]
  2. Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members. Hermey, G., Sjøgaard, S.S., Petersen, C.M., Nykjaer, A., Gliemann, J. Biochem. J. (2006) [Pubmed]
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