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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Afg3l1  -  AFG3-like AAA ATPase 1

Mus musculus

Synonyms: 1700047G05Rik, 3110061K15Rik, AFG3-like protein 1
 
 
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High impact information on Afg3l1

  • Homo-oligomeric Afg3l1 and Afg3l2 complexes and hetero-oligomeric assemblies of both proteins with paraplegin can be formed [1].
  • Like the other ATP-dependent zinc metalloproteases, Afg3l1 localizes to the mitochondria [2].

References

  1. Variable and Tissue-Specific Subunit Composition of Mitochondrial m-AAA Protease Complexes Linked to Hereditary Spastic Paraplegia. Koppen, M., Metodiev, M.D., Casari, G., Rugarli, E.I., Langer, T. Mol. Cell. Biol. (2007) [Pubmed]
  2. Molecular and functional analyses of the human and mouse genes encoding AFG3L1, a mitochondrial metalloprotease homologous to the human spastic paraplegia protein. Kremmidiotis, G., Gardner, A.E., Settasatian, C., Savoia, A., Sutherland, G.R., Callen, D.F. Genomics (2001) [Pubmed]
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