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Gene Review

YTA12  -  m-AAA protease subunit YTA12

Saccharomyces cerevisiae S288c

Synonyms: Mitochondrial respiratory chain complexes assembly protein YTA12, RCA1, Tat-binding homolog 12, YM9582.14C, YMR089C
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High impact information on YTA12

  • The mitochondrial members of the highly conserved AAA family, Yta10p and Yta12p, constitute a membrane-embedded complex of about 850 kDa [1].
  • Afg3p and Rca1p are adenosine triphosphate (ATP)-dependent metalloproteases in yeast mitochondria [2].
  • Studies with strains with mutations in the RAS-cAMP pathway and supplementation of a rca1 mutant with cAMP show that CTT1 expression is under negative control by a cAMP-dependent protein kinase and that nutrient control of CTT1 gene expression is mediated by this pathway [3].
  • The primary structure of Rca1 protein indicates several distinct domains in addition to the common purine nucleotide binding region shared by all members of this protein family [4].
  • The RCA1 gene has been cloned by complementation of an rca1 mutant with a yeast genomic library [4].

Biological context of YTA12


Anatomical context of YTA12


Other interactions of YTA12

  • Bypass of AFG3 and RCA1, whose products are essential for assembly of mitochondrial inner membrane enzyme complexes, suggests a related role for MBA1 [7].
  • Three genes for mitochondrial proteins suppress null-mutations in both Afg3 and Rca1 when over-expressed [8].
  • Most importantly, ADD appeared to be specifically suppressed to various extents by deletions of any of the YME1, AFG3, or RCA1 genes encoding membrane-associated mitochondrial proteases, probably because the amphipathic structures caused a stronger association with the mitochondrial inner membrane and its associated proteases [9].


  1. The YTA10-12 complex, an AAA protease with chaperone-like activity in the inner membrane of mitochondria. Arlt, H., Tauer, R., Feldmann, H., Neupert, W., Langer, T. Cell (1996) [Pubmed]
  2. Promotion of mitochondrial membrane complex assembly by a proteolytically inactive yeast Lon. Rep, M., van Dijl, J.M., Suda, K., Schatz, G., Grivell, L.A., Suzuki, C.K. Science (1996) [Pubmed]
  3. Control of Saccharomyces cerevisiae catalase T gene (CTT1) expression by nutrient supply via the RAS-cyclic AMP pathway. Bissinger, P.H., Wieser, R., Hamilton, B., Ruis, H. Mol. Cell. Biol. (1989) [Pubmed]
  4. A new member of a family of ATPases is essential for assembly of mitochondrial respiratory chain and ATP synthetase complexes in Saccharomyces cerevisiae. Tzagoloff, A., Yue, J., Jang, J., Paul, M.F. J. Biol. Chem. (1994) [Pubmed]
  5. The formation of respiratory chain complexes in mitochondria is under the proteolytic control of the m-AAA protease. Arlt, H., Steglich, G., Perryman, R., Guiard, B., Neupert, W., Langer, T. EMBO J. (1998) [Pubmed]
  6. The mitochondrial inner membrane AAA metalloprotease family in metazoans. Juhola, M.K., Shah, Z.H., Grivell, L.A., Jacobs, H.T. FEBS Lett. (2000) [Pubmed]
  7. MBA1 encodes a mitochondrial membrane-associated protein required for biogenesis of the respiratory chain. Rep, M., Grivell, L.A. FEBS Lett. (1996) [Pubmed]
  8. Three genes for mitochondrial proteins suppress null-mutations in both Afg3 and Rca1 when over-expressed. Rep, M., Nooy, J., Guélin, E., Grivell, L.A. Curr. Genet. (1996) [Pubmed]
  9. Enhanced mitochondrial degradation of yeast cytochrome c with amphipathic structures. Chen, X., Moerschell, R.P., Pearce, D.A., Ramanan, D.D., Sherman, F. Curr. Genet. (2005) [Pubmed]
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