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Gene Review:

Cgnz1 - chronic glomerulonephritis in NZM 1

Mus musculus

Waters, S.T. et al., Waters, S.T. et al.

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Disease relevance of Cgnz1

In lupus-prone NZM2328 mice, a locus Cgnz1 on chromosome 1 was linked to chronic glomerulonephritis, severe proteinuria, and early mortality in females [1].

High impact information on Cgnz1

One of them (Cgnz1) is on the telomeric end of chromosome 1 and close to Sle1 [2].

References

Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis. Waters, S.T., McDuffie, M., Bagavant, H., Deshmukh, U.S., Gaskin, F., Jiang, C., Tung, K.S., Fu, S.M. J. Exp. Med. (2004) [Pubmed]
NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci. Waters, S.T., Fu, S.M., Gaskin, F., Deshmukh, U.S., Sung, S.S., Kannapell, C.C., Tung, K.S., McEwen, S.B., McDuffie, M. Clin. Immunol. (2001) [Pubmed]

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