The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Proteinuria


Psychiatry related information on Proteinuria

  • ESRD risk reduction was predicted by basal proteinuria (P < 0.01) and GFR (P < 0.0001) and was strongly dependent on treatment duration (P < 0.0001) [5].
  • The clinical and laboratory features were not significantly different from those reported in large series of patients with SLE, except for less pleuritis and a trend toward less proteinuria, hallucinations, thrombopenia, and leukopenia [6].
  • Four months after a booster injection of 16/6 Id, the young mice developed clinical manifestations of SLE, including proteinuria and leukopenia, which were seen, in milder form, in the aged mice [7].

High impact information on Proteinuria


Chemical compound and disease context of Proteinuria

  • Blood glucose levels and proteinuria [13].
  • All control patients treated with prednisone alone continued to relapse at the same rate, with all patients experiencing a return of proteinuria by seven months [14].
  • Nineteen of 24 patients in whom proteinuria developed were positive for HLA-B8 and HLA-DRW3 antigens; 14 of 15 episodes of aurothiomalate-induced proteinura and nine of 13 episodes of penicillamine-induced proteinura occurred in patients with these antigens [15].
  • The rate of development of proteinuria and mortality were significantly retarded in these conditioned mice relative to untreated controls and nonconditioned animals that received unpaired treatment with saccharin and cyclophosphamide [16].
  • Ribavirin was effective in prolonging survival, reducing the titer of antibodies to DNA, and reversing proteinuria [17].
  • Compared to no sirolimus, sirolimus use was associated with higher prevalence of proteinuria (40% vs. 76%, p < 0.0001) and higher protein excretion (378 + 997 vs. 955 + 1986 mg/day, p < 0.0001) [18].

Biological context of Proteinuria

  • The decrease in proteinuria did not coincide with a fall in systemic blood pressure or in the blood glucose concentration [12].
  • Similarly, patients with AGT MT and TT genotypes had higher maximal values of proteinuria than those with the MM genotype (i.e., median values, 2.5 and 3.5 vs. 2.0 g/d, respectively; P < 0.02 by Kruskal-Wallis test) [19].
  • Furthermore, administering Gas6(-/-) mice recombinant wild-type Gas6, but not Gas6 lacking a previously characterized N-terminal gamma-carboxyl group, induced massive proteinuria, glomerular cell proliferation, and glomerulosclerosis, comparable to responses seen in wild-type mice [20].
  • Lowering renal plasma flow by 24% during indomethacin therapy in seven patients resulted in a 74% reduction in proteinuria accompanied by a corresponding diminution of filtrate formed through the shunt pathway [21].
  • Cyclooxygenase inhibition resulted in normalization of glomerular eicosanoid generation rates, amelioration of proteinuria, afferent vasoconstriction, and normalization of SNPF, delta P, Kf, and GFR [22].

Anatomical context of Proteinuria

  • Deleting MCP-1 dramatically reduces macrophage and T cell recruitment but not proliferation, protects from kidney, lung, skin, and lymph node pathology, reduces proteinuria, and prolongs survival [23].
  • Preliminary results showed that the rats developed moderate proteinuria (100 mg/ml protein in urine), which was associated with the presence of hyaline droplets in renal tubules, on the third day [24].
  • A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis [25].
  • Also, bFGF induced proteinuria and podocyte damage in rats injected with 10% of the regular PHN-serum dose [26].
  • Disappearance of this plasma cell subset during treatment was associated with decreases in anti-double-stranded DNA (anti-dsDNA) Ab levels, proteinuria, and SLE disease activity index [27].

Gene context of Proteinuria


Analytical, diagnostic and therapeutic context of Proteinuria


  1. Prevalence and pathologic features of sickle cell nephropathy and response to inhibition of angiotensin-converting enzyme. Falk, R.J., Scheinman, J., Phillips, G., Orringer, E., Johnson, A., Jennette, J.C. N. Engl. J. Med. (1992) [Pubmed]
  2. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Boute, N., Gribouval, O., Roselli, S., Benessy, F., Lee, H., Fuchshuber, A., Dahan, K., Gubler, M.C., Niaudet, P., Antignac, C. Nat. Genet. (2000) [Pubmed]
  3. A randomized controlled trial of prednisone in patients with idiopathic membranous nephropathy. Cattran, D.C., Delmore, T., Roscoe, J., Cole, E., Cardella, C., Charron, R., Ritchie, S. N. Engl. J. Med. (1989) [Pubmed]
  4. Mutation of the PAX2 gene in a family with optic nerve colobomas, renal anomalies and vesicoureteral reflux. Sanyanusin, P., Schimmenti, L.A., McNoe, L.A., Ward, T.A., Pierpont, M.E., Sullivan, M.J., Dobyns, W.B., Eccles, M.R. Nat. Genet. (1995) [Pubmed]
  5. ACE inhibitors to prevent end-stage renal disease: when to start and why possibly never to stop: a post hoc analysis of the REIN trial results. Ramipril Efficacy in Nephropathy. Ruggenenti, P., Perna, A., Remuzzi, G. J. Am. Soc. Nephrol. (2001) [Pubmed]
  6. Pure red cell aplasia and lupus. Habib, G.S., Saliba, W.R., Froom, P. Semin. Arthritis Rheum. (2002) [Pubmed]
  7. Effects of aging on the induction of experimental systemic lupus erythematosus (SLE) in mice. Tomer, Y., Mendlovic, S., Kukulansky, T., Mozes, E., Shoenfeld, Y., Globerson, A. Mech. Ageing Dev. (1991) [Pubmed]
  8. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. Brenner, B.M., Cooper, M.E., de Zeeuw, D., Keane, W.F., Mitch, W.E., Parving, H.H., Remuzzi, G., Snapinn, S.M., Zhang, Z., Shahinfar, S. N. Engl. J. Med. (2001) [Pubmed]
  9. Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis. Hong Kong-Guangzhou Nephrology Study Group. Chan, T.M., Li, F.K., Tang, C.S., Wong, R.W., Fang, G.X., Ji, Y.L., Lau, C.S., Wong, A.K., Tong, M.K., Chan, K.W., Lai, K.N. N. Engl. J. Med. (2000) [Pubmed]
  10. A controlled trial of fish oil in IgA nephropathy. Mayo Nephrology Collaborative Group. Donadio, J.V., Bergstralh, E.J., Offord, K.P., Spencer, D.C., Holley, K.E. N. Engl. J. Med. (1994) [Pubmed]
  11. Clinical and laboratory findings in the oculocerebrorenal syndrome of Lowe, with special reference to growth and renal function. Charnas, L.R., Bernardini, I., Rader, D., Hoeg, J.M., Gahl, W.A. N. Engl. J. Med. (1991) [Pubmed]
  12. Effect of captopril on heavy proteinuria in azotemic diabetics. Taguma, Y., Kitamoto, Y., Futaki, G., Ueda, H., Monma, H., Ishizaki, M., Takahashi, H., Sekino, H., Sasaki, Y. N. Engl. J. Med. (1985) [Pubmed]
  13. Blood glucose levels and proteinuria. Silva, F.G., Weber, C.J., Pirani, C.L., Hardy, M.A., Reemtsma, K. N. Engl. J. Med. (1979) [Pubmed]
  14. Chlorambucil treatment of frequently relapsing nephrotic syndrome. Grupe, W.E., Makker, S.P., Ingelfinger, J.R. N. Engl. J. Med. (1976) [Pubmed]
  15. HLA-DR antigens and toxic reaction to sodium aurothiomalate and D-penicillamine in patients with rheumatoid arthritis. Wooley, P.H., Griffin, J., Panayi, G.S., Batchelor, J.R., Welsh, K.I., Gibson, T.J. N. Engl. J. Med. (1980) [Pubmed]
  16. Behaviorally conditioned immunosuppression and murine systemic lupus erythematosus. Ader, R., Cohen, N. Science (1982) [Pubmed]
  17. Ribavirin: efficacy in the treatment of murine autoimmune disease. Klassen, L.W., Budman, D.R., Williams, G.W., Steinberg, A.D., Gerber, N.L. Science (1977) [Pubmed]
  18. Proteinuria after kidney transplantation, relationship to allograft histology and survival. Amer, H., Fidler, M.E., Myslak, M., Morales, P., Kremers, W.K., Larson, T.S., Stegall, M.D., Cosio, F.G. Am. J. Transplant. (2007) [Pubmed]
  19. Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients. Pei, Y., Scholey, J., Thai, K., Suzuki, M., Cattran, D. J. Clin. Invest. (1997) [Pubmed]
  20. Essential role of Gas6 for glomerular injury in nephrotoxic nephritis. Yanagita, M., Ishimoto, Y., Arai, H., Nagai, K., Ito, T., Nakano, T., Salant, D.J., Fukatsu, A., Doi, T., Kita, T. J. Clin. Invest. (2002) [Pubmed]
  21. Nature of the glomerular capillary injury in human membranous glomerulopathy. Shemesh, O., Ross, J.C., Deen, W.M., Grant, G.W., Myers, B.D. J. Clin. Invest. (1986) [Pubmed]
  22. Predominant functional roles for thromboxane A2 and prostaglandin E2 during late nephrotoxic serum glomerulonephritis in the rat. Takahashi, K., Schreiner, G.F., Yamashita, K., Christman, B.W., Blair, I., Badr, K.F. J. Clin. Invest. (1990) [Pubmed]
  23. Monocyte chemoattractant protein 1-dependent leukocytic infiltrates are responsible for autoimmune disease in MRL-Fas(lpr) mice. Tesch, G.H., Maifert, S., Schwarting, A., Rollins, B.J., Kelley, V.R. J. Exp. Med. (1999) [Pubmed]
  24. Podoendin. A new cell surface protein of the podocyte and endothelium. Huang, T.W., Langlois, J.C. J. Exp. Med. (1985) [Pubmed]
  25. A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis. Tang, T., Rosenkranz, A., Assmann, K.J., Goodman, M.J., Gutierrez-Ramos, J.C., Carroll, M.C., Cotran, R.S., Mayadas, T.N. J. Exp. Med. (1997) [Pubmed]
  26. Basic fibroblast growth factor augments podocyte injury and induces glomerulosclerosis in rats with experimental membranous nephropathy. Floege, J., Kriz, W., Schulze, M., Susani, M., Kerjaschki, D., Mooney, A., Couser, W.G., Koch, K.M. J. Clin. Invest. (1995) [Pubmed]
  27. Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions. Grammer, A.C., Slota, R., Fischer, R., Gur, H., Girschick, H., Yarboro, C., Illei, G.G., Lipsky, P.E. J. Clin. Invest. (2003) [Pubmed]
  28. Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome. Kestilä, M., Lenkkeri, U., Männikkö, M., Lamerdin, J., McCready, P., Putaala, H., Ruotsalainen, V., Morita, T., Nissinen, M., Herva, R., Kashtan, C.E., Peltonen, L., Holmberg, C., Olsen, A., Tryggvason, K. Mol. Cell (1998) [Pubmed]
  29. Idiopathic low molecular weight proteinuria associated with hypercalciuric nephrocalcinosis in Japanese children is due to mutations of the renal chloride channel (CLCN5). Lloyd, S.E., Pearce, S.H., Günther, W., Kawaguchi, H., Igarashi, T., Jentsch, T.J., Thakker, R.V. J. Clin. Invest. (1997) [Pubmed]
  30. Bioactivity of glomerular ultrafiltrate during heavy proteinuria may contribute to renal tubulo-interstitial lesions: evidence for a role for insulin-like growth factor I. Hirschberg, R. J. Clin. Invest. (1996) [Pubmed]
  31. Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains. Huber, T.B., Simons, M., Hartleben, B., Sernetz, L., Schmidts, M., Gundlach, E., Saleem, M.A., Walz, G., Benzing, T. Hum. Mol. Genet. (2003) [Pubmed]
  32. Inhibition of complement regulation is key to the pathogenesis of active Heymann nephritis. Schiller, B., He, C., Salant, D.J., Lim, A., Alexander, J.J., Quigg, R.J. J. Exp. Med. (1998) [Pubmed]
  33. Contribution of genetic polymorphism in the renin-angiotensin system to the development of renal complications in insulin-dependent diabetes: Genetique de la Nephropathie Diabetique (GENEDIAB) study group. Marre, M., Jeunemaitre, X., Gallois, Y., Rodier, M., Chatellier, G., Sert, C., Dusselier, L., Kahal, Z., Chaillous, L., Halimi, S., Muller, A., Sackmann, H., Bauduceau, B., Bled, F., Passa, P., Alhenc-Gelas, F. J. Clin. Invest. (1997) [Pubmed]
  34. Endothelin-1 mRNA expression by peripheral blood monocytes in IgA nephropathy. Nakamura, T., Ebihara, I., Shirato, I., Fukui, M., Tomino, Y., Koide, H. Lancet (1993) [Pubmed]
  35. Treatment of intractable lupus nephritis with total lymphoid irradiation. Strober, S., Field, E., Hoppe, R.T., Kotzin, B.L., Shemesh, O., Engleman, E., Ross, J.C., Myers, B.D. Ann. Intern. Med. (1985) [Pubmed]
  36. Experimental glomerulopathy alters renal cortical cholesterol, SR-B1, ABCA1, and HMG CoA reductase expression. Johnson, A.C., Yabu, J.M., Hanson, S., Shah, V.O., Zager, R.A. Am. J. Pathol. (2003) [Pubmed]
WikiGenes - Universities