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Gene Review

arcA  -  two component signal transduction system...

Shewanella oneidensis MR-1

 
 
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Disease relevance of arcA

  • The Arc two-component system plays an important role in this process in Escherichia coli; therefore, we determined its function in S. oneidensis. arcA from S. oneidensis complements an E. coli arcA mutant, but the Arc regulon in S. oneidensis constitutes a different suite of genes [1].
 

High impact information on arcA

  • We demonstrate that these genes encode a functional DMSO reductase, and that an arcA mutant cannot fully induce their expression and is defective in growing on DMSO under anaerobic conditions [1].
  • Biofilms of null mutants in arcA and crp were severely impacted in the stop-of-flow-induced detachment response, suggesting a role for these genes in regulation of detachment [2].

References

  1. Anaerobic regulation by an atypical Arc system in Shewanella oneidensis. Gralnick, J.A., Brown, C.T., Newman, D.K. Mol. Microbiol. (2005) [Pubmed]
  2. Induction of rapid detachment in Shewanella oneidensis MR-1 biofilms. Thormann, K.M., Saville, R.M., Shukla, S., Spormann, A.M. J. Bacteriol. (2005) [Pubmed]
 
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