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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Terms

 

Gene Review: 

Amy1  -  amylase 1, salivary

Mus musculus

Synonyms: 1,4-alpha-D-glucan glucanohydrolase 1, Alpha-amylase 1, Amy-1, Amy-1-a, Amy1a, ...
 
 
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Disease relevance of Amy1

 

High impact information on Amy1

  • Adult mouse liver expressed Amy-1 and Amy-2 at levels comparable to those of fully induced hepatoma cells [2].
  • Amy-1 is constitutively active in these cells and is inducible by dexamethasone at the level of mRNA [1].
  • The tissue-specific expression of two types of mouse amylase genes does not overlap in vivo; the Amy-1 locus is transcribed in the parotid gland and the liver, while expression of Amy-2 is limited to the pancreas [1].
  • The genetic location of the breakpoint in the reciprocal translocation T(2:3)24H is placed between the Amy-1 and Va loci [3].
  • A new simplified method for determining the Amy-1 and Amy-2 genotype of mice is presented [3].
 

Analytical, diagnostic and therapeutic context of Amy1

  • Quantitative analysis of genomic DNA by Southern blotting provided direct evidence for duplication of Amy-1 in strain YBR [4].

References

  1. Simultaneous expression of salivary and pancreatic amylase genes in cultured mouse hepatoma cells. Darlington, G.J., Tsai, C.C., Samuelson, L.C., Gumucio, D.L., Meisler, M.H. Mol. Cell. Biol. (1986) [Pubmed]
  2. Glucocorticoid and developmental regulation of amylase mRNAs in mouse liver cells. Samuelson, L.C., Keller, P.R., Darlington, G.J., Meisler, M.H. Mol. Cell. Biol. (1988) [Pubmed]
  3. Assignment of LH XVI to chromosome 3 in the mouse. Eicher, E.M., Lane, P.W. J. Hered. (1980) [Pubmed]
  4. Interstrain variation in amylase gene copy number and mRNA abundance in three mouse tissues. Meisler, M.H., Antonucci, T.K., Treisman, L.O., Gumucio, D.L., Samuelson, L.C. Genetics (1986) [Pubmed]
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