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MeSH Review

Blotting, Southern

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Disease relevance of Blotting, Southern


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High impact information on Blotting, Southern

  • By Southern blot and 3'-RACE analysis, we demonstrate consistent rearrangements in HMGI-C and/or expression of altered HMGI-C transcripts [7].
  • Interphase in situ results and Southern blot analysis indicate that several further YRRM sequences map within interval 6 [8].
  • We conducted a case-control study, typing 736 HRAS1 alleles from patients with cancer and 652 from controls by Southern blotting of leukocyte DNA [9].
  • Southern blot analyses suggest that pallid is a mutation in the Epb4.2 gene [10].
  • A quantitative end-labeling assay showed that the level of m5C in the DNA of homozygous mutant cells was about one-third that of wild-type cells, and Southern blot analysis after cleavage of the DNA with a methylation-sensitive restriction endonuclease revealed substantial demethylation of endogenous retroviral DNA [11].

Chemical compound and disease context of Blotting, Southern


Biological context of Blotting, Southern


Anatomical context of Blotting, Southern


Associations of Blotting, Southern with chemical compounds

  • The continued presence of T-DNA sequences in shoots is directly demonstrated by Southern blotting and is also revealed by the presence of the tumor markers octopine and nopaline [27].
  • The evolutionary lineage of these genes compared to the known functional locus lambda C1-lambda C6 can be surmised from Southern blot and nucleotide homologies [28].
  • Southern blot analysis showed that cells continuously propagated in methionine-supplemented medium (J10met), unlike cells grown in normal medium, progressively segregated the hu-H-ras-1 gene [29].
  • DNA methylation was assessed by cytosine extension assay and by Southern blotting [30].
  • METHODS: Effects of an intragastric dose of ethanol (5 g/kg) on hepatic mitochondrial DNA levels, structure, and synthesis were determined by slot blot hybridization, Southern blot hybridization, and in vivo [3H]thymidine incorporation, respectively [31].

Gene context of Blotting, Southern

  • Altered patterns of expression of Mdm2 proteins were determined using an immunohistochemical assay with monoclonal antibody 2A10, and MDM2 gene amplifications were studied by Southern blotting [32].
  • Expression of BCRP messenger RNA (mRNA) and amplification of the BCRP gene were analyzed by northern and Southern blot hybridization, respectively [33].
  • METHODS: We performed Southern blot analysis in 112 patients from MLH1-, MSH2-, and MSH6-negative HNPCC-like families [34].
  • Southern blot analysis of the MUC1 gene was performed on 57 Northern European patients to determine TR allele lengths [35].
  • Southern blot analysis and RNA dot blot analysis demonstrated that the ER variants had lost the amplified EGFR gene [36].

Analytical, diagnostic and therapeutic context of Blotting, Southern


  1. Allelic loss of chromosome 1p as a predictor of unfavorable outcome in patients with neuroblastoma. Caron, H., van Sluis, P., de Kraker, J., Bökkerink, J., Egeler, M., Laureys, G., Slater, R., Westerveld, A., Voûte, P.A., Versteeg, R. N. Engl. J. Med. (1996) [Pubmed]
  2. Isolation of a feline leukaemia provirus containing the oncogene myc from a feline lymphosarcoma. Levy, L.S., Gardner, M.B., Casey, J.W. Nature (1984) [Pubmed]
  3. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nobori, T., Miura, K., Wu, D.J., Lois, A., Takabayashi, K., Carson, D.A. Nature (1994) [Pubmed]
  4. Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene. Dalla-Favera, R., Gallo, R.C., Giallongo, A., Croce, C.M. Science (1982) [Pubmed]
  5. Persistence of human T cell lymphotropic virus type 1 (HTLV-1) sequences in peripheral blood mononuclear cells from patients with mycosis fungoides. Manca, N., Piacentini, E., Gelmi, M., Calzavara, P., Manganoni, M.A., Glukhov, A., Gargiulo, F., De Francesco, M., Pirali, F., De Panfilis, G., Turano, A. J. Exp. Med. (1994) [Pubmed]
  6. mRNA expression of serotonin receptors of type 2C and 5A in human resting lymphocytes. Marazziti, D., Ori, M., Nardini, M., Rossi, A., Nardi, I., Cassano, G.B. Neuropsychobiology (2001) [Pubmed]
  7. Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Schoenmakers, E.F., Wanschura, S., Mols, R., Bullerdiek, J., Van den Berghe, H., Van de Ven, W.J. Nat. Genet. (1995) [Pubmed]
  8. A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. Ma, K., Inglis, J.D., Sharkey, A., Bickmore, W.A., Hill, R.E., Prosser, E.J., Speed, R.M., Thomson, E.J., Jobling, M., Taylor, K. Cell (1993) [Pubmed]
  9. An association between the risk of cancer and mutations in the HRAS1 minisatellite locus. Krontiris, T.G., Devlin, B., Karp, D.D., Robert, N.J., Risch, N. N. Engl. J. Med. (1993) [Pubmed]
  10. The murine pallid mutation is a platelet storage pool disease associated with the protein 4.2 (pallidin) gene. White, R.A., Peters, L.L., Adkison, L.R., Korsgren, C., Cohen, C.M., Lux, S.E. Nat. Genet. (1992) [Pubmed]
  11. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Li, E., Bestor, T.H., Jaenisch, R. Cell (1992) [Pubmed]
  12. Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy. Arnaudo, E., Dalakas, M., Shanske, S., Moraes, C.T., DiMauro, S., Schon, E.A. Lancet (1991) [Pubmed]
  13. Cloning and characterization of human colon glyoxalase-I. Ranganathan, S., Walsh, E.S., Godwin, A.K., Tew, K.D. J. Biol. Chem. (1993) [Pubmed]
  14. Linkage analysis of the Bcg gene on mouse chromosome 1. Identification of a tightly linked marker. Schurr, E., Skamene, E., Forget, A., Gros, P. J. Immunol. (1989) [Pubmed]
  15. Demonstration of Epstein-Barr viral DNA in formalin-fixed, paraffin-embedded samples of Hodgkin's disease. Libetta, C.M., Pringle, J.H., Angel, C.A., Craft, A.W., Malcolm, A.J., Lauder, I. J. Pathol. (1990) [Pubmed]
  16. High levels of genetic recombination among cotransfected plasmid DNAs in poxvirus-infected mammalian cells. Evans, D.H., Stuart, D., McFadden, G. J. Virol. (1988) [Pubmed]
  17. DNA sequence variants in the G gamma-, A gamma-, delta- and beta-globin genes of man. Jeffreys, A.J. Cell (1979) [Pubmed]
  18. A DNA polymorphism, consistent with gene duplication, correlates with high renin levels in the mouse submaxillary gland. Piccini, N., Knopf, J.L., Gross, K.W. Cell (1982) [Pubmed]
  19. Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene. Joyner, A.L., Kornberg, T., Coleman, K.G., Cox, D.R., Martin, G.R. Cell (1985) [Pubmed]
  20. Gene transfer into humans--immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. Rosenberg, S.A., Aebersold, P., Cornetta, K., Kasid, A., Morgan, R.A., Moen, R., Karson, E.M., Lotze, M.T., Yang, J.C., Topalian, S.L. N. Engl. J. Med. (1990) [Pubmed]
  21. Alterations of INK4A and INK4B genes in adult soft tissue sarcomas: effect on survival. Orlow, I., Drobnjak, M., Zhang, Z.F., Lewis, J., Woodruff, J.M., Brennan, M.F., Cordon-Cardo, C. J. Natl. Cancer Inst. (1999) [Pubmed]
  22. Alterations of the hprt gene in human in vivo-derived 6-thioguanine-resistant T lymphocytes. Albertini, R.J., O'Neill, J.P., Nicklas, J.A., Heintz, N.H., Kelleher, P.C. Nature (1985) [Pubmed]
  23. MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status. Flørenes, V.A., Maelandsmo, G.M., Forus, A., Andreassen, A., Myklebost, O., Fodstad, O. J. Natl. Cancer Inst. (1994) [Pubmed]
  24. Relation of mesangial IgA glomerulonephritis to polymorphism of immunoglobulin heavy chain switch region. Demaine, A.G., Rambausek, M., Knight, J.F., Williams, D.G., Welsh, K.I., Ritz, E. J. Clin. Invest. (1988) [Pubmed]
  25. Inherited idiopathic dilated cardiomyopathy with multiple deletions of mitochondrial DNA. Suomalainen, A., Paetau, A., Leinonen, H., Majander, A., Peltonen, L., Somer, H. Lancet (1992) [Pubmed]
  26. Association between poor prognosis in early-stage invasive cervical carcinomas and non-detection of HPV DNA. Riou, G., Favre, M., Jeannel, D., Bourhis, J., Le Doussal, V., Orth, G. Lancet (1990) [Pubmed]
  27. Retention of tumor markers in F1 progeny plants from in vitro induced octopine and nopaline tumor tissues. Wullems, G.J., Molendijk, L., Ooms, G., Schilperoort, R.A. Cell (1981) [Pubmed]
  28. Identification of three new Ig lambda-like genes in man. Chang, H., Dmitrovsky, E., Hieter, P.A., Mitchell, K., Leder, P., Turoczi, L., Kirsch, I.R., Hollis, G.F. J. Exp. Med. (1986) [Pubmed]
  29. Loss of the oncogene from human H-ras-1-transfected NIH/3T3 cells grown in the presence of excess methionine. Hillova, J., Hill, M., Belehradek, J., Mariage-Samson, R., Brada, Z. J. Natl. Cancer Inst. (1986) [Pubmed]
  30. Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia. Ingrosso, D., Cimmino, A., Perna, A.F., Masella, L., De Santo, N.G., De Bonis, M.L., Vacca, M., D'Esposito, M., D'Urso, M., Galletti, P., Zappia, V. Lancet (2003) [Pubmed]
  31. An alcoholic binge causes massive degradation of hepatic mitochondrial DNA in mice. Mansouri, A., Gaou, I., De Kerguenec, C., Amsellem, S., Haouzi, D., Berson, A., Moreau, A., Feldmann, G., Lettéron, P., Pessayre, D., Fromenty, B. Gastroenterology (1999) [Pubmed]
  32. Altered patterns of MDM2 and TP53 expression in human bladder cancer. Lianes, P., Orlow, I., Zhang, Z.F., Oliva, M.R., Sarkis, A.S., Reuter, V.E., Cordon-Cardo, C. J. Natl. Cancer Inst. (1994) [Pubmed]
  33. Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines. Ross, D.D., Yang, W., Abruzzo, L.V., Dalton, W.S., Schneider, E., Lage, H., Dietel, M., Greenberger, L., Cole, S.P., Doyle, L.A. J. Natl. Cancer Inst. (1999) [Pubmed]
  34. Heterozygous mutations in PMS2 cause hereditary nonpolyposis colorectal carcinoma (Lynch syndrome). Hendriks, Y.M., Jagmohan-Changur, S., van der Klift, H.M., Morreau, H., van Puijenbroek, M., Tops, C., van Os, T., Wagner, A., Ausems, M.G., Gomez, E., Breuning, M.H., Bröcker-Vriends, A.H., Vasen, H.F., Wijnen, J.T. Gastroenterology (2006) [Pubmed]
  35. Altered expression and allelic association of the hypervariable membrane mucin MUC1 in Helicobacter pylori gastritis. Vinall, L.E., King, M., Novelli, M., Green, C.A., Daniels, G., Hilkens, J., Sarner, M., Swallow, D.M. Gastroenterology (2002) [Pubmed]
  36. Two independent mechanisms for escaping epidermal growth factor-mediated growth inhibition in epidermal growth factor receptor-hyperproducing human tumor cells. Hirai, M., Gamou, S., Minoshima, S., Shimizu, N. J. Cell Biol. (1988) [Pubmed]
  37. Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway. Buchberg, A.M., Cleveland, L.S., Jenkins, N.A., Copeland, N.G. Nature (1990) [Pubmed]
  38. Identification of an astrocyte cell population from human brain that expresses perforin, a cytotoxic protein implicated in immune defense. Gasque, P., Jones, J., Singhrao, S.K., Morgan, B. J. Exp. Med. (1998) [Pubmed]
  39. Human eosinophils express transforming growth factor alpha. Wong, D.T., Weller, P.F., Galli, S.J., Elovic, A., Rand, T.H., Gallagher, G.T., Chiang, T., Chou, M.Y., Matossian, K., McBride, J. J. Exp. Med. (1990) [Pubmed]
  40. Expression of aquaporin-4 in fast-twitch fibers of mammalian skeletal muscle. Frigeri, A., Nicchia, G.P., Verbavatz, J.M., Valenti, G., Svelto, M. J. Clin. Invest. (1998) [Pubmed]
  41. LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice. Lu, H., Smith, C.W., Perrard, J., Bullard, D., Tang, L., Shappell, S.B., Entman, M.L., Beaudet, A.L., Ballantyne, C.M. J. Clin. Invest. (1997) [Pubmed]
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