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Gene Review

CLK3  -  CDC-like kinase 3

Homo sapiens

Synonyms: Dual specificity protein kinase CLK3, PHCLK3, PHCLK3/152, clk3
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High impact information on CLK3

  • In this study, we demonstrate that the human Clk2 and Clk3 (hClk2 and 3) are also found within the nucleus and display dual-specificity kinase activity [1].
  • Clk3 is involved in regulating RNA splicing [2].


  1. The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. Duncan, P.I., Stojdl, D.F., Marius, R.M., Scheit, K.H., Bell, J.C. Exp. Cell Res. (1998) [Pubmed]
  2. Identification of differentially expressed genes during a wool follicle growth cycle induced by prolactin. Rufaut, N.W., Pearson, A.J., Nixon, A.J., Wheeler, T.T., Wilkins, R.J. J. Invest. Dermatol. (1999) [Pubmed]
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