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Gene Review

CLK2  -  CDC-like kinase 2

Homo sapiens

Synonyms: Dual specificity protein kinase CLK2, clk2
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Disease relevance of CLK2


Psychiatry related information on CLK2


High impact information on CLK2


Biological context of CLK2


Anatomical context of CLK2

  • RESULTS AND CONCLUSIONS: In our dataset, GUSB and CLK2 were the best choices as reference genes for EBV-LCLs and fibroblasts, respectively [8].

Associations of CLK2 with chemical compounds

  • Our results indicate that persistent repair intermediates and/or single-stranded DNA formed during repair of misincorporated uracil are tolerated in the absence of the CLK-2 checkpoint in C. elegans [6].

Other interactions of CLK2

  • In this study, we demonstrate that the human Clk2 and Clk3 (hClk2 and 3) are also found within the nucleus and display dual-specificity kinase activity [9].


  1. Functional hemizygosity of PAFAH1B3 due to a PAFAH1B3-CLK2 fusion gene in a female with mental retardation, ataxia and atrophy of the brain. Nothwang, H.G., Kim, H.G., Aoki, J., Geisterfer, M., Kübart, S., Wegner, R.D., van Moers, A., Ashworth, L.K., Haaf, T., Bell, J., Arai, H., Tommerup, N., Ropers, H.H., Wirth, J. Hum. Mol. Genet. (2001) [Pubmed]
  2. The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer's disease. Glatz, D.C., Rujescu, D., Tang, Y., Berendt, F.J., Hartmann, A.M., Faltraco, F., Rosenberg, C., Hulette, C., Jellinger, K., Hampel, H., Riederer, P., Möller, H.J., Andreadis, A., Henkel, K., Stamm, S. J. Neurochem. (2006) [Pubmed]
  3. Human tra2-beta1 autoregulates its protein concentration by influencing alternative splicing of its pre-mRNA. Stoilov, P., Daoud, R., Nayler, O., Stamm, S. Hum. Mol. Genet. (2004) [Pubmed]
  4. Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease. Winfield, S.L., Tayebi, N., Martin, B.M., Ginns, E.I., Sidransky, E. Genome Res. (1997) [Pubmed]
  5. Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation. Jiang, N., Bénard, C.Y., Kébir, H., Shoubridge, E.A., Hekimi, S. J. Biol. Chem. (2003) [Pubmed]
  6. Abrogation of the CLK-2 checkpoint leads to tolerance to base-excision repair intermediates. Dengg, M., Garcia-Muse, T., Gill, S.G., Ashcroft, N., Boulton, S.J., Nilsen, H. EMBO Rep. (2006) [Pubmed]
  7. Latent herpes simplex virus infection of sensory neurons alters neuronal gene expression. Kramer, M.F., Cook, W.J., Roth, F.P., Zhu, J., Holman, H., Knipe, D.M., Coen, D.M. J. Virol. (2003) [Pubmed]
  8. Comparison of 12 reference genes for normalization of gene expression levels in Epstein-Barr virus-transformed lymphoblastoid cell lines and fibroblasts. de Brouwer, A.P., van Bokhoven, H., Kremer, H. Molecular diagnosis & therapy. (2006) [Pubmed]
  9. The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. Duncan, P.I., Stojdl, D.F., Marius, R.M., Scheit, K.H., Bell, J.C. Exp. Cell Res. (1998) [Pubmed]
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