Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ags - hypothetical protein

Agrobacterium tumefaciens

Hong, S.B. et al.

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Disease relevance of ags

Expression of ags from the lac promoter conferred mannopine-lactonizing activity on Escherichia coli [1].
Agrobacterium tumefaciens strains harboring an octopine-type Ti plasmid exhibit a similar activity which is not coded for by ags [1].

High impact information on ags

Analysis of the DNA sequence of the gene encoding this activity, called agcA, showed it to be about 60% identical to T-DNA ags genes [1].
The pathway for the biosynthesis of the opine agropine is thought to require an enzyme, mannopine cyclase, coded for by the ags gene located in the T(R) region of octopine-type Ti plasmids [1].
Tumor cells containing a T region in which ags was mutated lacked this activity and did not contain agropine [1].

References

A T-DNA gene required for agropine biosynthesis by transformed plants is functionally and evolutionarily related to a Ti plasmid gene required for catabolism of agropine by Agrobacterium strains. Hong, S.B., Hwang, I., Dessaux, Y., Guyon, P., Kim, K.S., Farrand, S.K. J. Bacteriol. (1997) [Pubmed]

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