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Gene Review: 

relA  -  GTP pyrophosphokinase (ATP:GTP 3'...

Sinorhizobium meliloti 1021

 
 
 
 
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Disease relevance of relA

  • The intracellular pathogen Brucella spp., causative agent of brucellosis, possesses a gene homologous to relA/spoT, named rsh, encoding a (p)ppGpp synthetase as confirmed by heterologous complementation of a relA mutant of Sinorhizobium meliloti [1].

References

  1. The stringent response mediator Rsh is required for Brucella melitensis and Brucella suis virulence, and for expression of the type IV secretion system virB. Dozot, M., Boigegrain, R.A., Delrue, R.M., Hallez, R., Ouahrani-Bettache, S., Danese, I., Letesson, J.J., De Bolle, X., K??hler, S. Cell. Microbiol. (2006) [Pubmed]
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