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Gene Review

lon  -  Lon protease

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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High impact information on lon

  • Taken together, the impaired ability of the lon disruption mutant to survive and grow in macrophages could be due to the enhanced susceptibility to the oxygen-dependent killing mechanism associated with respiratory burst and the low phagosomal pH [1].
  • Macrophage survival assays revealed that the lon disruption mutant could not survive or proliferate within murine macrophages [1].


  1. Lon, a stress-induced ATP-dependent protease, is critically important for systemic Salmonella enterica serovar typhimurium infection of mice. Takaya, A., Suzuki, M., Matsui, H., Tomoyasu, T., Sashinami, H., Nakane, A., Yamamoto, T. Infect. Immun. (2003) [Pubmed]
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