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Gene Review:

msgA - virulence protein MsgA

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Gunn, J.S. et al., Takaya, A. et al., Takaya, A. et al.

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Disease relevance of msgA

The low G + C content of these genes and the homology of msgA to Shigella plasmid DNA suggest that this region may have been acquired by horizontal transmission [1].

High impact information on msgA

Macrophage survival assays revealed that the DnaK/DnaJ-depleted mutant could not survive or proliferate at all within macrophages [2].
Macrophage survival assays revealed that the lon disruption mutant could not survive or proliferate within murine macrophages [3].
Each gene is transcribed from its own promoter, two of which (msgA and pagD) were defined by primer extension analysis [1].

References

Characterization of the Salmonella typhimurium pagC/pagD chromosomal region. Gunn, J.S., Alpuche-Aranda, C.M., Loomis, W.P., Belden, W.J., Miller, S.I. J. Bacteriol. (1995) [Pubmed]
The DnaK/DnaJ chaperone machinery of Salmonella enterica serovar Typhimurium is essential for invasion of epithelial cells and survival within macrophages, leading to systemic infection. Takaya, A., Tomoyasu, T., Matsui, H., Yamamoto, T. Infect. Immun. (2004) [Pubmed]
Lon, a stress-induced ATP-dependent protease, is critically important for systemic Salmonella enterica serovar typhimurium infection of mice. Takaya, A., Suzuki, M., Matsui, H., Tomoyasu, T., Sashinami, H., Nakane, A., Yamamoto, T. Infect. Immun. (2003) [Pubmed]

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