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Gene Review:

pgtE - outer membrane protease E

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Grodberg, J. et al., Lähteenmäki, K. et al., Chen, H. et al.

Lähteenmäki, Kyllönen, Partanen, Korhonen,

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Disease relevance of pgtE

Construction, characterization, and immunogenicity of an attenuated Salmonella enterica serovar typhimurium pgtE vaccine expressing fimbriae with integrated viral epitopes from the spiC promoter [1].
In this paper, it is shown that pgtE codes for a protein functionally homologous to OmpT as judged by its ability to proteolyze T7 RNA polymerase and to localize in the outer membrane of E. coli [2].

High impact information on pgtE

The lysate from S. enterica 14028-infected macrophages promoted formation of plasmin in the presence of alpha(2)AP, whereas plasmin formation by lysates from uninfected macrophages, or from macrophages infected with the pgtE-negative derivative of 14028, was inhibited by alpha(2)AP [3].
The predicted amino acid sequence of OmpT, an Escherichia coli outer membrane protease, was found to be highly homologous to that predicted for the pgtE gene product of Salmonella typhimurium [2].

References

Construction, characterization, and immunogenicity of an attenuated Salmonella enterica serovar typhimurium pgtE vaccine expressing fimbriae with integrated viral epitopes from the spiC promoter. Chen, H., Schifferli, D.M. Infect. Immun. (2003) [Pubmed]
Comparison of Escherichia coli K-12 outer membrane protease OmpT and Salmonella typhimurium E protein. Grodberg, J., Dunn, J.J. J. Bacteriol. (1989) [Pubmed]
Antiprotease inactivation by Salmonella enterica released from infected macrophages. Lähteenmäki, K., Kyllönen, P., Partanen, L., Korhonen, T.K. Cell. Microbiol. (2005) [Pubmed]

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