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Gene Review

sptP  -  secreted effector protein SptP

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of sptP

  • Salmonella serotype Typhimurium strains having mutations in sptP, avrA, sspH1, or slrP induced fluid secretion in the bovine ligated ileal loop model at levels similar to that of the wild type [1].

High impact information on sptP

  • In contrast, mutations in sipA and sptP, which also encode secreted proteins, did not interfere with the translocation of SipC, indicating that only a subset of targets of the type III secretion system act as translocases [2].
  • A loss-of-function mutation in sicP resulted in drastically reduced levels of SptP but did not affect sptP expression, indicating that SicP exerts its effect posttranscriptionally [3].


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