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Gene Review:

sptP - secreted effector protein SptP

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Collazo, C.M. et al., Zhang, S. et al., Fu, Y. et al.

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Disease relevance of sptP

Salmonella serotype Typhimurium strains having mutations in sptP, avrA, sspH1, or slrP induced fluid secretion in the bovine ligated ileal loop model at levels similar to that of the wild type [1].

High impact information on sptP

In contrast, mutations in sipA and sptP, which also encode secreted proteins, did not interfere with the translocation of SipC, indicating that only a subset of targets of the type III secretion system act as translocases [2].
A loss-of-function mutation in sicP resulted in drastically reduced levels of SptP but did not affect sptP expression, indicating that SicP exerts its effect posttranscriptionally [3].

References

The Salmonella enterica serotype typhimurium effector proteins SipA, SopA, SopB, SopD, and SopE2 act in concert to induce diarrhea in calves. Zhang, S., Santos, R.L., Tsolis, R.M., Stender, S., Hardt, W.D., Bäumler, A.J., Adams, L.G. Infect. Immun. (2002) [Pubmed]
The invasion-associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cell. Collazo, C.M., Galán, J.E. Mol. Microbiol. (1997) [Pubmed]
Identification of a specific chaperone for SptP, a substrate of the centisome 63 type III secretion system of Salmonella typhimurium. Fu, Y., Galán, J.E. J. Bacteriol. (1998) [Pubmed]

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