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Gene Review

slrP  -  E3 ubiquitin-protein ligase SlrP

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of slrP

  • This pathogenicity islet contained a single gene, termed slrP, with homology to ipaH of Shigella flexneri and yopM of Yersinia pestis [1].
  • Salmonella serotype Typhimurium strains having mutations in sptP, avrA, sspH1, or slrP induced fluid secretion in the bovine ligated ileal loop model at levels similar to that of the wild type [2].


  1. Identification of a putative Salmonella enterica serotype typhimurium host range factor with homology to IpaH and YopM by signature-tagged mutagenesis. Tsolis, R.M., Townsend, S.M., Miao, E.A., Miller, S.I., Ficht, T.A., Adams, L.G., Bäumler, A.J. Infect. Immun. (1999) [Pubmed]
  2. The Salmonella enterica serotype typhimurium effector proteins SipA, SopA, SopB, SopD, and SopE2 act in concert to induce diarrhea in calves. Zhang, S., Santos, R.L., Tsolis, R.M., Stender, S., Hardt, W.D., Bäumler, A.J., Adams, L.G. Infect. Immun. (2002) [Pubmed]
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