Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

rpsD - 30S ribosomal protein S4

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Björkman, J. et al.

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Disease relevance of rpsD

To test whether ram mutants could reverse this loss of virulence, we have isolated a set of rpsD alleles in Salmonella typhimurium [1].

High impact information on rpsD

Furthermore, all seven rpsD alleles (four ram and three restrictive) can phenotypically reverse the hyperaccuracy associated with restrictive alleles of rpsL [1].
Dependence on streptomycin and hyperaccuracy can each be reversed phenotypically by mutations in either rpsD or rpsE [1].
This is the first demonstration that such compensations do not require that the compensating rpsD allele has a ribosomal ambiguity (ram) phenotype [1].

References

Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium. Björkman, J., Samuelsson, P., Andersson, D.I., Hughes, D. Mol. Microbiol. (1999) [Pubmed]

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