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Gene Review

bnrdE  -  ribunucleotide reductase large subunit

Bacillus phage SPbeta

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Disease relevance of bnrdE

  • The two putative ribonucleotide reductase subunits of the Bacillus subtilis bacteriophage SPbeta are encoded by the bnrdE and bnrdF genes that are highly similar to corresponding host paralogs, located on the opposite replication arm [1].

High impact information on bnrdE

  • The bnrdF intron contains an ORF encoding a polypeptide similar to homing endonucleases responsible for intron mobility, whereas the bnrdE intron has no obvious trace of coding sequence [1].
  • In addition, bnrdE provides an example of a group I intron and an intein coding sequence within the same gene [1].


  1. Introns and intein coding sequence in the ribonucleotide reductase genes of Bacillus subtilis temperate bacteriophage SPbeta. Lazarevic, V., Soldo, B., Düsterhöft, A., Hilbert, H., Mauël, C., Karamata, D. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
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