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Gene Review

Cox5b  -  cytochrome c oxidase subunit Vb

Mus musculus

Synonyms: Cytochrome c oxidase polypeptide Vb, Cytochrome c oxidase subunit 5B, mitochondrial
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Disease relevance of Cox5b

  • Using the adenovirus E1A oncoprotein, we show that p300/CBP acts as a coactivator in the USF2-dependent activation of the Cox5b Inr [1].

High impact information on Cox5b

  • Domains of USF2 encoded by exon 4, exon 5 and the USF-specific region are important for maximum activation of the Cox5b Inr [1].
  • Importantly, using a dominant-negative mutant of USF2, we demonstrate the role of endogenous USF2 proteins in the transcriptional activation of the Cox5b Inr [1].
  • In this article, we demonstrate that the mouse cytochrome c oxidase subunit Vb gene (Cox5b) can be transactivated by ectopic expression of USF2 through an initiator (Inr) element in the core promoter [1].


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