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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Adenoviridae

  • We show that derivatives of the yeast transcriptional activator GAL4, synthesized in and purified from E. coli, stimulate transcription of a mammalian gene (the adenovirus E4 gene) in a HeLa cell nuclear extract [1].
  • Selective cleavage of U4 or U6 RNA in a HeLa cell nuclear extract inhibits splicing of pre-mRNAs containing an adenovirus or a simian virus 40 intron [2].
  • We have introduced adenovirus 2 genes into high molecular weight DNA of permissive human cells by co-transformation of tk- human 143 cells with Ad2 restriction enzyme fragments and a cloned Bam HI fragment that carries the HSV-1 thymidine kinase gene [3].
  • Three cellular proteins, including species of 300,000 daltons and 107,000 daltons as well as p105-RB, the product of the retinoblastoma susceptibility gene, stably interact with the adenovirus E1A proteins [4].
  • Specifically, the HPV-16 E7 gene product could transactivate the adenovirus E2 promoter and cooperate with an activated ras oncogene to transform primary baby rat kidney cells [5].

Psychiatry related information on Adenoviridae


High impact information on Adenoviridae


Chemical compound and disease context of Adenoviridae

  • Adenovirus contains a heterodimeric protein complex consisting of 186 kd fiber protein that mediates high affinity virus attachment to cells and a 400 kd pentavalent subunit (penton base) that contains five Arg-Gly-Asp sequences, implying a role for integrins in adenovirus infection [12].
  • These data indicate that adenovirus attachment and uptake into cells are separate but cooperative events that result from the interaction of distinct viral coat proteins with a receptor for attachment and alpha v integrin receptors for internalization [12].
  • A short sequence in the COOH-terminus makes an adenovirus membrane glycoprotein a resident of the endoplasmic reticulum [13].
  • It is proposed that the adenovirus protease is a cysteine protease and that its activation by the peptide involves thiol-disulphide interchange, which serves to expose the active site cysteine [14].
  • The messenger RNAs encoding two late adenovirus serotype 2 (Ad2) proteins, fiber and 100K, were purified by hybridization to restriction endonuclease fragments of Ad2 DNA followed by electrophoresis on polyacrylamide gels containing 98% formamide [15].

Biological context of Adenoviridae

  • One of these CCAAT-binding proteins, CP1, binds with high affinity to CCAAT elements present in the human alpha-globin promoter and the adenovirus major late promoter (MLP) [16].
  • A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein [17].
  • We conclude that CTF/NF-I can serve both as a transcription selectivity factor for RNA polymerase II and as an initiation factor for adenovirus DNA replication [18].
  • VA-RNA was found to hybridize exculsively to the l-strand [strand with low buoyant density in CsCl when complexed with poly(U,G)] of a segment of the viral DNA which is located between positions 0.27 and 0.32 on the unit map of the adenovirus type 2 genome [19].
  • The adenovirus type 5 E1A enhancer contains two functionally distinct domains: one is specific for E1A and the other modulates all early units in cis [20].

Anatomical context of Adenoviridae


Gene context of Adenoviridae

  • The E7 transforming function differed somewhat from that of adenovirus E1A in that E7 was also able to transform established mouse cells [5].
  • Moreover, the adenovirus E1A protein can dissociate the E2F-RB complex, dependent on E1A sequence also critical for E1A to bind to RB [26].
  • Furthermore, three distinct DNA tumour virus groups--papovaviruses, adenoviruses and human papillomaviruses--transform cells by targeting and inactivating certain functions of both the p53 and retinoblastoma proteins [27].
  • Specifically, we demonstrate that overexpression of the E2F1 complementary DNA can activate DNA synthesis in cells that would otherwise growth-arrest, with an efficiency that is similar to that achieved by the expression of the adenovirus E1A gene [28].
  • This provides a new mechanism for inhibition of the IFN-alpha-activated antiviral response by E1A, and supports the view that E1A binding to p300/CBP has functional significance for adenovirus replication in its natural host [29].

Analytical, diagnostic and therapeutic context of Adenoviridae


  1. GAL4 derivatives function alone and synergistically with mammalian activators in vitro. Lin, Y.S., Carey, M.F., Ptashne, M., Green, M.R. Cell (1988) [Pubmed]
  2. Pre-mRNA splicing in vitro requires intact U4/U6 small nuclear ribonucleoprotein. Black, D.L., Steitz, J.A. Cell (1986) [Pubmed]
  3. Expression of unselected adenovirus genes in human cells co-transformed with the HSV-1 tk gene and adenovirus 2 DNA. Grodzicker, T., Klessig, D.F. Cell (1980) [Pubmed]
  4. Cellular targets for transformation by the adenovirus E1A proteins. Whyte, P., Williamson, N.M., Harlow, E. Cell (1989) [Pubmed]
  5. The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A. Phelps, W.C., Yee, C.L., Münger, K., Howley, P.M. Cell (1988) [Pubmed]
  6. Medial hypothalamic 5-hydroxytryptamine (5-HT)1A receptors regulate neuroendocrine responses to stress and exploratory locomotor activity: application of recombinant adenovirus containing 5-HT1A sequences. Li, Q., Holmes, A., Ma, L., Van de Kar, L.D., Garcia, F., Murphy, D.L. J. Neurosci. (2004) [Pubmed]
  7. Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A. Hamamori, Y., Sartorelli, V., Ogryzko, V., Puri, P.L., Wu, H.Y., Wang, J.Y., Nakatani, Y., Kedes, L. Cell (1999) [Pubmed]
  8. Ectopic expression of thyrotropin releasing hormone (TRH) receptors in liver modulates organ function to regulate blood glucose by TRH. Wolff, G., Mastrangeli, A., Heinflink, M., Falck-Pedersen, E., Gershengorn, M.C., Crystal, R.G. Nat. Genet. (1996) [Pubmed]
  9. Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein. Fagan, R., Flint, K.J., Jones, N. Cell (1994) [Pubmed]
  10. Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Crystal, R.G., McElvaney, N.G., Rosenfeld, M.A., Chu, C.S., Mastrangeli, A., Hay, J.G., Brody, S.L., Jaffe, H.A., Eissa, N.T., Danel, C. Nat. Genet. (1994) [Pubmed]
  11. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. Boyd, J.M., Malstrom, S., Subramanian, T., Venkatesh, L.K., Schaeper, U., Elangovan, B., D'Sa-Eipper, C., Chinnadurai, G. Cell (1994) [Pubmed]
  12. Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Wickham, T.J., Mathias, P., Cheresh, D.A., Nemerow, G.R. Cell (1993) [Pubmed]
  13. A short sequence in the COOH-terminus makes an adenovirus membrane glycoprotein a resident of the endoplasmic reticulum. Pääbo, S., Bhat, B.M., Wold, W.S., Peterson, P.A. Cell (1987) [Pubmed]
  14. The adenovirus protease is activated by a virus-coded disulphide-linked peptide. Webster, A., Hay, R.T., Kemp, G. Cell (1993) [Pubmed]
  15. Two adenovirus mRNAs have a common 5' terminal leader sequence encoded at least 10 kb upstream from their main coding regions. Klessig, D.F. Cell (1977) [Pubmed]
  16. Human CCAAT-binding proteins have heterologous subunits. Chodosh, L.A., Baldwin, A.S., Carthew, R.W., Sharp, P.A. Cell (1988) [Pubmed]
  17. A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein. Liu, F., Green, M.R. Cell (1990) [Pubmed]
  18. A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication. Jones, K.A., Kadonaga, J.T., Rosenfeld, P.J., Kelly, T.J., Tjian, R. Cell (1987) [Pubmed]
  19. Location of sequences on the adenovirus genome coding for the 5.5S RNA. Pettersson, U., Philipson, L. Cell (1975) [Pubmed]
  20. The adenovirus type 5 E1A enhancer contains two functionally distinct domains: one is specific for E1A and the other modulates all early units in cis. Hearing, P., Shenk, T. Cell (1986) [Pubmed]
  21. In vitro traits of adenovirus-transformed cell lines and their relevance to tumorigenicity in nude mice. Gallimore, P.H., McDougall, J.K., Chen, L.B. Cell (1977) [Pubmed]
  22. Nuclear RNA is spliced in the absence of poly(A) addition. Zeevi, M., Nevins, J.R., Darnell, J.E. Cell (1981) [Pubmed]
  23. Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors. Bajocchi, G., Feldman, S.H., Crystal, R.G., Mastrangeli, A. Nat. Genet. (1993) [Pubmed]
  24. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Flores, E.R., Tsai, K.Y., Crowley, D., Sengupta, S., Yang, A., McKeon, F., Jacks, T. Nature (2002) [Pubmed]
  25. CD46 is a cellular receptor for group B adenoviruses. Gaggar, A., Shayakhmetov, D.M., Lieber, A. Nat. Med. (2003) [Pubmed]
  26. The E2F transcription factor is a cellular target for the RB protein. Chellappan, S.P., Hiebert, S., Mudryj, M., Horowitz, J.M., Nevins, J.R. Cell (1991) [Pubmed]
  27. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Xiao, Z.X., Chen, J., Levine, A.J., Modjtahedi, N., Xing, J., Sellers, W.R., Livingston, D.M. Nature (1995) [Pubmed]
  28. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Johnson, D.G., Schwarz, J.K., Cress, W.D., Nevins, J.R. Nature (1993) [Pubmed]
  29. Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Bhattacharya, S., Eckner, R., Grossman, S., Oldread, E., Arany, Z., D'Andrea, A., Livingston, D.M. Nature (1996) [Pubmed]
  30. Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Yang, Y., Nunes, F.A., Berencsi, K., Gönczöl, E., Engelhardt, J.F., Wilson, J.M. Nat. Genet. (1994) [Pubmed]
  31. Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses. Engelhardt, J.F., Yang, Y., Stratford-Perricaudet, L.D., Allen, E.D., Kozarsky, K., Perricaudet, M., Yankaskas, J.R., Wilson, J.M. Nat. Genet. (1993) [Pubmed]
  32. Long-term correction of mouse dystrophic degeneration by adenovirus-mediated transfer of a minidystrophin gene. Vincent, N., Ragot, T., Gilgenkrantz, H., Couton, D., Chafey, P., Grégoire, A., Briand, P., Kaplan, J.C., Kahn, A., Perricaudet, M. Nat. Genet. (1993) [Pubmed]
  33. Sequence analysis of adenovirus DNA: complete nucleotide sequence of the spliced 5' noncoding region of adenovirus 2 hexon messenger RNA. Akusjärvi, G., Pettersson, U. Cell (1979) [Pubmed]
  34. Activated Akt protects the lung from oxidant-induced injury and delays death of mice. Lu, Y., Parkyn, L., Otterbein, L.E., Kureishi, Y., Walsh, K., Ray, A., Ray, P. J. Exp. Med. (2001) [Pubmed]
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